Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Cobalt-containing Enzymes

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_71



Among the metals of the first transition series,  cobalt (Co) is next to iron (Fe) and exhibits three oxidation states (+1, +2, and +3) much like its congener iron (+2, +3, and +4). However, unlike iron, it is present in a relatively small number of enzymes and cofactors (Kobayashi and Shimizu 1999). In addition, it does not participate in oxygen activation, a process that iron frequently takes part in. In the +3 oxidation state,  cobalt enjoys high crystal field stabilization energy (CFSE) in several coordination geometries. Significantly, high stability arises when Co3+ exists in spin-paired (low-spin) electronic configuration within an octahedral coordination environment of strong ligands. Such stability often makes the Co3+center resistant to substitution processes such as exchange of a bound water molecule for the substrate. Such a center however can serve as a...

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of ChemistryUniversity of GeorgiaAthensUSA
  2. 2.Department of Chemistry and BiochemistryUniversity of CaliforniaSanta CruzUSA