Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Sarcoplasmic Calcium-Binding Protein Family: SCP, Calerythrin, Aequorin, and Calexcitin

  • Jos A. Cox
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_68



A family of intracellular calcium-binding proteins, spread over all forms of life, from bacteria to vertebrate neuronal tissues, have a very similar three-dimensional structure, characteristic, and unique for this family, and involved in a variety of functions including intracellular calcium buffering, bioluminescence, enzymatic activity and associative learning.


Calcium ions (Ca2+) are essential for the normal function of the cell. A transient rise of the intracellular Ca2+ concentration is achieved by its entering the cell through various plasma membrane Ca2+ channels and/or by being liberated from various internal stores after an appropriate stimulus. The rise and fall of intracellular Ca2+ is very versatile and different in different cell types, with very local ion gradients, hot spots, waves, and oscillations.  Calcium-binding proteins(CaBP) have been...

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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of BiochemistryUniversity of GenevaGenevaSwitzerland