Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Calcium in Biological Systems

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_66

Synonyms

Definition

The variation in the concentration of free Ca2+ ion within the cytosol over time is a form of information. This information can be transduced into a change in protein conformation and/or enzyme activity by interaction with a calcium-modulated protein(s).

Overview

Calcium is unique in biological systems. Ca2+ is the only metal cation demonstrated to function as a secondary messenger in the cytosol of eukaryotes. The information in this pulse of Ca2+ ions (Berridge 2006) is transduced into a change of conformation of a calcium-modulated protein(s). Many of these calcium-modulated proteins contain two to twelve tandem EF-hand domains. Others contain one or two C2 domains or four annexin domains. Numerous calcium channels and calcium pumps in the membranes of the cell and its various organelles, especially the endoplasmic reticulum, are involved in...

This is a preview of subscription content, log in to check access

References

  1. Berridge MJ (2006) Calcium microdomains: organization and function. Cell Calcium 40:405–412CrossRefPubMedGoogle Scholar
  2. Hofer AM (2005) Another dimension to calcium signaling: a look at extracellular calcium. J Cell Sci 118:855–862CrossRefPubMedGoogle Scholar
  3. Lowenstam HA, Weiner S (1989) On biomineralization. Oxford University Press, New YorkGoogle Scholar
  4. Mann S (2001) Biomineralization: principles and concepts in bioinorganic materials chemistry. Oxford University Press, New YorkGoogle Scholar
  5. Nakayama S, Kawasaki H, Kretsinger RH (2000) Evolution of EF-hand proteins. Top Biol Inorg Chem 3:29–58Google Scholar
  6. Permyakov EA, Kretsinger RH (2009) Cell signaling, beyond cytosolic calcium in eukaryotes. J Inorg Biochem 103:77–86CrossRefPubMedGoogle Scholar
  7. Permyakov EA, Kretsinger RH (2010) Calcium binding proteins. John Wiley, HobokenCrossRefGoogle Scholar
  8. Whitiker M (ed) (2010) Calcium in living cells methods in cell biology, vol 99. Elsevier/Academic, BurlingtonGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of BiologyUniversity of VirginiaCharlottesvilleUSA