Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Calcium in Heart Function and Diseases

  • Giuseppe Inesi
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_60

Synonyms

Definition

Ca2+ signaling refers to coupling of membrane excitation to contractile activation of heart muscle. Mechanisms permitting cyclic rise and reduction of Ca2+ concentration within cardiac muscle cells are required for optimal heart beating. Alterations of these mechanisms are followed by deficient contraction and relaxation.

Introduction

Ca2+ signaling serves as a common mechanism to couple membrane excitation to intracellular functions in most biological tissues (Clapham 2007). This mechanism is based on: (a) a high gradient between extracellular (or intracellular stores) Ca2+ concentration (mM) and intracellular (cytosolic) Ca2+ concentration (0.1 μM); (b) passive fluxes of signaling Ca2+through selective channels from extracellular fluids (or intracellular stores) into the cytosol; (c) the presence of intracellular proteins, such as calmodulin and troponin,...

This is a preview of subscription content, log in to check access.

Notes

Acknowledgments

The author is partially supported by NHLBI Grant RO1-69830

References

  1. Bers DM (2008) Calcium cycling and signaling in cardiac myocytes. Annu Rev Physiol 70:23–49CrossRefPubMedGoogle Scholar
  2. Cavagna M, O’Donnell JM, Sumbilla C, Inesi G, Klein MG (2000) Exogenous Ca2+-ATPase isoform effects on Ca2+ transients of embryonic chicken and neonatal rat cardiac myocytes. J Physiol 528:53–63CrossRefPubMedGoogle Scholar
  3. Clapham DE (2007) Calcium signaling. Cell 131(6):1047–1058CrossRefPubMedGoogle Scholar
  4. Del Monte F, Hajjar RJ (2003) Targeting calcium cycling proteins in heart failure through gene transfer. J Physiol 546:49–61CrossRefPubMedGoogle Scholar
  5. Inesi G, Sumbilla C, Kirtley ME (1990) Relationships of molecular structure and function in Ca2+ transport ATPase. Physiol Rev 70(3):749–760PubMedGoogle Scholar
  6. MacLennan DH, Kranias EG (2003) Phospholamban: a crucial regulator of cardiac contractility. Nat Rev Mol Cell Biol 4:566–577CrossRefPubMedGoogle Scholar
  7. Periasamy M, Kalyanasundaram A (2007) SERCA pump isoforms: their role in calcium transport and disease. Muscle Nerve 35(4):430–442CrossRefPubMedGoogle Scholar
  8. Prasad AM, Inesi G (2009) Effects of thapsigargin and phenylephrine on calcineurin and protein kinase C signaling functions in cardiac myocytes. Am J Physiol Cell Physiol 296(5):C992–C1002CrossRefPubMedGoogle Scholar
  9. Prasad AM, Inesi G (2010) Downregulation of Ca2+ signalling proteins in cardiac hypertrophy. Minerva Cardioangiol 58(2):193–204PubMedGoogle Scholar
  10. Toyoshima C, Inesi G (2004) Structural basis of ion pumping by Ca2± ATPase of the sarcoplasmic reticulum. Annu Rev Biochem 73:269–292CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.California Pacific Medical Center Research InstituteSan FranciscoUSA