Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Silver-Induced Conformational Changes of Polypeptides

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_576

Synonyms

Definition

Polypeptides are polymers of amino acids linked by peptide bonds with various levels of organization. The alternative structures of the same polypeptide are referred to as different conformations, and transitions between them are called conformational changes. Silver binding to polypeptides is known to induce conformational changes, which are different from those produced by other heavy metals, such as copper, mercury, nickel, etc. The toxicity degree of silver ions seems to be modulated by their ability to change peptide and protein conformations. Glycine-rich polypeptides undergo severe conformational changes depending on the environmental conditions and especially the presence of silver ions. Contrary to other metal ions, such as copper, iron, nickel, or mercury ones, silver binding may reduce β-sheet or β-turn conformations, with the corresponding increase in the α-helical ones.

Conformation of...

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Alexandru Ioan Cuza University of IasiIasiRomania