Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Calcium and Mitochondrion

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_57



Calcium: An alkaline earth metal having atomic number 20, typically found in the 2+ oxidation state.

Mitochondrion (plural: mitochondria): An intracellular organelle noted for being the site of oxidative phosphorylation and for producing over 90% of the ATP in a typical animal cell.

Importance of Mitochondrial Ca2+ Transport

Mitochondrial Ca2+ transport is known to perform three functions: (1) to activate steps in the metabolic pathways and increase the rate of ATP production, (2) to modify the shape and distribution of cytosolic Ca2+ transients, and (3) to induce the mitochondrial permeability transition in mitochondrially induced apoptosis or programmed cell death. These functions are extremely important. Intramitochondrial free Ca2+ concentration ([Ca2+]m) activates important steps in the metabolic pathways, such as pyruvate dehydrogenase, α-ketoglutarate dehydrogenase, isocitrate dehydrogenase, and the F1F0ATP synthase, which taken...

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Biochemistry and BiophysicsUniversity of Rochester School of Medicine and DentistryRochesterUSA