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Silver, Pharmacological and Toxicological Profile as Antimicrobial Agent in Medical Devices

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Encyclopedia of Metalloproteins
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Synonyms

Colloidal silver; Metal-binding proteins; Metallothioneins; Nanocrystalline silver; Silver; Silver sulfadiazine

Definition

Silver is a white lustrous transitional metallic element found widely in the human environment. Low concentrations of silver accumulate in the human body through inhalation of particles in the air and contamination of the diet and drinking water. Silver serves no trace metal value in the human body. Increasing use of silver as an antibacterial and antifungal agent in wound care products, medical devices (bone cements, catheters, surgical sutures, cardiovascular prostheses, and dental fillings), textiles, cosmetics, and even domestic appliances in recent years has lead to concern as to the safety aspects of the metal and potential risks associated with absorption of the biologically active Ag+ into the human body.

Silver exists in its elemental form in natural deposits and in complexes with lead, copper, arsenic, and mercury. Metallic silver is inert in the...

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References

  • Armitage SA, White MA, Wilson HK (1996) The determination of silver in whole blood and its application to biological monitoring of occupationally exposed groups. Ann Occup Hyg 40:331–338

    CAS  PubMed  Google Scholar 

  • Bleehen SS, Gould DJ, Harrington CI, Durrant TE, Slater DN, Underwood JC (1981) Occupational argyria; light and electron microscopic studies and X-ray microanalysis. Br J Dermatol 104:19–26

    Article  CAS  PubMed  Google Scholar 

  • Burrell RE (2003) A scientific perspective on the use of topical silver preparations. Ostomy Wound Manage 49:19–24

    PubMed  Google Scholar 

  • Choban PS, Marshall WJ (1987) Leukopenia secondary to silver sulfadiazine: frequency, characteristics and clinical consequences. Am Surg 53:515–517

    CAS  PubMed  Google Scholar 

  • Coombs CJ, Wan AT, Masterton JP, Conyers RAJ, Pedersen J, Chia YT (1992) Do burn patients have a silver lining. Burns 18:179–184

    Article  CAS  PubMed  Google Scholar 

  • Di Vincenzo GD, Giordano CJ, Schriever LS (1985) Biologic monitoring of workers exposed to silver. Int Arch Occup Environ Health 56:207–215

    Article  Google Scholar 

  • East BW, Boddy K, Williams ED, Macintyre D, McLay AL (1980) Silver retention, total body silver and tissue silver concentrations in argyria associated with exposure to an anti-smoking remedy containing silver acetate. Clin Exp Dermatol 5:305–311

    Article  CAS  PubMed  Google Scholar 

  • Fisher AA (1987) Contact dermatitis. Lea and Febiger, Philadelphia

    Google Scholar 

  • Hidalgo E, Bartolome R, Barroso C, Moreno A, Domınguez C(1998) Silver nitrate: antimicrobial activity related to cytotoxicity in cultured human fibroblasts. Skin Pharmacol Appl Skin Physiol 11:140–151

    Article  CAS  PubMed  Google Scholar 

  • Lansdown ABG (2002) Metallothioneins: potential therapeutic aids for wound healing in the skin. Wound Repair Regen 10:130–132

    Article  PubMed  Google Scholar 

  • Lansdown ABG (2007) Critical observations on the neurotoxicity of silver. Crit Rev Toxicol 37:237–250

    Article  CAS  PubMed  Google Scholar 

  • Lansdown ABG (2010) Silver in healthcare: its antimicrobial efficacy and safety in use. Royal Society of Chemistry, Cambridge

    Google Scholar 

  • Lansdown ABG (2011) Metal ions affecting the skin and eyes. In: Sigel A, Sigel H, Sigel RO (eds) Metal ions in life sciences. Royal Society of Chemisty, Cambridge

    Google Scholar 

  • Lowbury EJL (1977) Problems of resistance in open wounds and burns. In: Mouton RP, Brumfitt W, Hamilton-Miller JMT (eds) The Rational Choice of Antibacterial Agents. Kluwer, London

    Google Scholar 

  • McCauley RL, Li YY, Chopra V, Herndon DN, Robson MC (1994) Cytoprotection of human dermal fibroblasts against silver sulfadiazine using recombinant growth factors. J Surg Res 56:378–384

    Article  CAS  PubMed  Google Scholar 

  • McHugh GL, Mollering RC, Hopkins CC, Swartz MN (1975) Salmonella typhimurium resistant to silver nitrate, chloramphenicol and ampicillin. Lancet 1:235–240

    Article  CAS  PubMed  Google Scholar 

  • Moss AP, Sugar A, Hargett NA (1979) The ocular manifestations and functional effects of occupational argyrosis. Arch Ophthalmol 97:906–908

    Article  CAS  PubMed  Google Scholar 

  • Silver S (2003) Bacterial silver resistance, molecular biology and uses and misuses of silver compounds. FEMS Microbiol Rev 27:341–353

    Article  CAS  PubMed  Google Scholar 

  • Tobin EJ, Bambauer R (2003) Silver- coating of dialysis catheters to reduce bacterial colonisation and infection. Ther Apher Dial 7:504–509

    Article  PubMed  Google Scholar 

  • U.S. EPA (1985) Drinking water criteria document for silver, Final Draft ECAO-CIN-026, The Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, for the Office of Drinking Water, Washington, DC

    Google Scholar 

  • Wan AT, Conyers RA, Coombs CJ, Masterton JP (1991) Determination of silver in blood, urine, and tissues of volunteers and burn patients. Clin Chem 37:1683–1687

    CAS  PubMed  Google Scholar 

  • World Health Organisation (1996) Silver in drinking water: background document for the development of WHO guideline for drinking water quality. WHO, Geneva, WHO/SDE/WSH/03.04/14

    Google Scholar 

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Correspondence to Alan B. G. Lansdown .

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Lansdown, A.B.G. (2013). Silver, Pharmacological and Toxicological Profile as Antimicrobial Agent in Medical Devices. In: Kretsinger, R.H., Uversky, V.N., Permyakov, E.A. (eds) Encyclopedia of Metalloproteins. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1533-6_562

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