Silver, Pharmacological and Toxicological Profile as Antimicrobial Agent in Medical Devices
Silver is a white lustrous transitional metallic element found widely in the human environment. Low concentrations of silver accumulate in the human body through inhalation of particles in the air and contamination of the diet and drinking water. Silver serves no trace metal value in the human body. Increasing use of silver as an antibacterial and antifungal agent in wound care products, medical devices (bone cements, catheters, surgical sutures, cardiovascular prostheses, and dental fillings), textiles, cosmetics, and even domestic appliances in recent years has lead to concern as to the safety aspects of the metal and potential risks associated with absorption of the biologically active Ag+ into the human body.
Silver exists in its elemental form in natural deposits and in complexes with lead, copper, arsenic, and mercury. Metallic silver is inert...
- Fisher AA (1987) Contact dermatitis. Lea and Febiger, PhiladelphiaGoogle Scholar
- Lansdown ABG (2010) Silver in healthcare: its antimicrobial efficacy and safety in use. Royal Society of Chemistry, CambridgeGoogle Scholar
- Lansdown ABG (2011) Metal ions affecting the skin and eyes. In: Sigel A, Sigel H, Sigel RO (eds) Metal ions in life sciences. Royal Society of Chemisty, CambridgeGoogle Scholar
- Lowbury EJL (1977) Problems of resistance in open wounds and burns. In: Mouton RP, Brumfitt W, Hamilton-Miller JMT (eds) The Rational Choice of Antibacterial Agents. Kluwer, LondonGoogle Scholar
- U.S. EPA (1985) Drinking water criteria document for silver, Final Draft ECAO-CIN-026, The Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, for the Office of Drinking Water, Washington, DCGoogle Scholar
- World Health Organisation (1996) Silver in drinking water: background document for the development of WHO guideline for drinking water quality. WHO, Geneva, WHO/SDE/WSH/03.04/14Google Scholar