Nanosilver, Next-Generation Antithrombotic Agent

Synonyms

Antithrombotic; Blood platelets; Cell signaling; Fibrin; Integrins; Nanobio conjugates; Silver nanoparticles (AgNPs)

Definition

Thrombolytic therapy in acute stroke has reduced ischemia; however, it is also associated with increased incidence of intracerebral hemorrhage and expanding stroke. Platelets and fibrin are the major components of thrombi and are an obvious target for majority of antithrombotic therapies. Silver nanoparticles have shown to have innate antiplatelet properties with nanosilver. It can effectively prevent platelet activation in response to physiological agonists, under both in vitro as well as ex vivo conditions, and immobilize and stabilize proteins. Furthermore, nanosilver can also significantly retard fibrin polymerization kinetics both in pure and plasma-incorporated systems and hence can impede thrombus formation. Together with its inherent antiplatelet and antibacterial properties, capacity to inhibit fibrin polymerization can open up possibilities...