Calcineurin: Calcineurin is a phosphatase that reverses the modification of proteins by kinase-mediated phosphorylation on either serine or threonine residues. Calcineurin requires Ca2+ and Ca2+-bound calmodulin for full activity. In different classification systems, calcineurin has also been labeled as PP2B or PP3.
Immunosuppressant: Drugs that inhibit the function of the immune system are termed immunosuppressants. Two commonly used immunosuppressants are cyclosporin A and FK506 (also called tacrolimus). Both of these immunosuppressants are also inhibitors of calcineurin.
Docking site: Docking sites, also termed docking motifs, are short linear sequences, 4–8 amino acids in length, which are contained within a substrate protein and mediate the...