Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Calcineurin

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_54

Synonyms

Definition

Calcineurin: Calcineurin is a phosphatase that reverses the modification of proteins by kinase-mediated phosphorylation on either serine or threonine residues. Calcineurin requires Ca2+ and Ca2+-bound calmodulin for full activity. In different classification systems, calcineurin has also been labeled as PP2B or PP3.

Immunosuppressant: Drugs that inhibit the function of the immune system are termed immunosuppressants. Two commonly used immunosuppressants are cyclosporin A and FK506 (also called tacrolimus). Both of these immunosuppressants are also inhibitors of calcineurin.

Docking site: Docking sites, also termed docking motifs, are short linear sequences, 4–8 amino acids in length, which are contained within a substrate protein and mediate the...

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References

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of BiologyStanford UniversityStanfordUSA