Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Silver, Burn Wound Sepsis and Healing

  • Bishara S. Atiyeh
  • Amir Ibrahim
  • Saad A. Dibo
  • Marwan S. Rizk
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_533



Topical treatment and burn wound dressings are an essential component of burn wound management. Several topical agents are being used to reduce surface colonization and prevent burn wound sepsis. Silver-based products have been most widely used over the last few decades and since the introduction of the silver-containing formulation, silver sulfadiazine (SSD) (Flamazine®, Silvadene®), by Fox shortly, silver became the main antibacterial prophylactic agent in burns and a viable treatment option for burn wounds, open wounds, and chronic ulcers. Nevertheless, the use of the many silver-containing products for burn wounds is still controversial and opinions in clinical practice conflicting.

Silver does possess antimicrobial properties. However, evidence of its effectiveness remains poorly defined and does not support its use for topical treatment. Silver does not appear to...

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Bishara S. Atiyeh
    • 1
  • Amir Ibrahim
    • 2
  • Saad A. Dibo
    • 3
  • Marwan S. Rizk
    • 4
  1. 1.Division of Plastic Surgery, Department of SurgeryAmerican University of Beirut Medical CenterBeirutLebanon
  2. 2.Plastic and Reconstructive SurgeryBurn Fellow, Massachusetts General Hospital / Harvard Medical School & Shriners Burn HospitalBostonUSA
  3. 3.Division Plastic and Reconstructive SurgeryAmerican University of Beirut Medical CenterBeirutLebanon
  4. 4.Deptartment of AnesthesiologyAmerican University of Beirut Medical CenterBeirutLebanon