Definition
Platinum-based anticancer drugs can bind to a range of proteins, especially at sulfur atoms, affecting their conformation and functions. One possible mechanism of resistance and toxicity induced by these drugs may be explained according to this interaction, relevant to the therapeutic effect.
One of the most important drugs employed in treating various types of cancers is cisplatin. Unlike most other drugs, cisplatin is a simple inorganic compound, [H6Cl2N2Pt] (cf. Fig. 1) (Che and Siu 2010). After administration, one of the chloride ligands at the cisplatin platinum center is displaced by water. Subsequent displacement of this water allows the platinum to coordinate to a nitrogen atom in DNA. Thereafter, cross-linking of two DNA bases may occur via displacement of the other chloride ligand from...
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References
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Silaghi-Dumitrescu, R., Bischin, C. (2013). Platinum-Containing Anticancer Drugs and Proteins, Interaction. In: Kretsinger, R.H., Uversky, V.N., Permyakov, E.A. (eds) Encyclopedia of Metalloproteins. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1533-6_532
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DOI: https://doi.org/10.1007/978-1-4614-1533-6_532
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