CusCFBA Copper/Silver Efflux System
Tripartite efflux complexes are protein export systems that span both membranes in Gram-negative bacteria and are involved in efflux of compounds from the cell. These systems are composed of three proteins: an inner membrane protein, an outer membrane protein, and a periplasmic adaptor that connects the two membrane proteins.
RND proteins are Resistance-nodulation-and cell division proteins. These are membrane proteins that expel compounds from bacterial cells using the protein gradient as an energy source. In Gram-negative tripartite efflux complexes, RND proteins are the inner membrane component.
MFPs are membrane fusion proteins; they function as the adaptors in the tripartite efflux complexes. They are also called periplasmic adaptor proteins.
Periplasm is the region between the inner and outer membranes in Gram-negative bacteria.
Several transition metals are necessary as trace...
- Mealman TD, Blackburn NJ, McEvoy MM (2012) Metal export by CusCFBA, the periplasmic Cu(I)/Ag(I) transport system of E. coli. Curr Top Membr (in press)Google Scholar