Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Colloidal Silver Nanoparticles and Bovine Serum Albumin

  • Vinita Ernest
  • N. Chandrasekaran
  • Amitava Mukherjee
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_526



Purposely modified silver nanoparticles (AgNPs) using bovine serum albumin (BSA) is a biofunctionalization technique to obtain biocompatibility in metals where the surface of the metal nanoparticle is altered for various biomedical applications. Among the serum albumins, the most abundant proteins in plasma and with a wide range of physiological functions, BSA has made it a model protein for biofunctionalization. BSA-coated AgNPs are being increasingly used in the recent past as sensors for environmental pollutants, targeted drug delivery, diagnostics, biosensors owing to exceptional biocompatibility, and optoelectronic properties. Besides functionalizing the nanoparticles for such uses, it highly stabilizes the nanoparticle, thereby preventing from aggregation and agglomeration, which is a major limitation for the application of nanoparticle in biological systems.

Principles and Role of BSA...

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Vinita Ernest
    • 1
  • N. Chandrasekaran
    • 1
  • Amitava Mukherjee
    • 1
  1. 1.Centre for NanobiotechnologyVIT UniversityVelloreIndia