Colloidal Silver Nanoparticles and Bovine Serum Albumin
Purposely modified silver nanoparticles (AgNPs) using bovine serum albumin (BSA) is a biofunctionalization technique to obtain biocompatibility in metals where the surface of the metal nanoparticle is altered for various biomedical applications. Among the serum albumins, the most abundant proteins in plasma and with a wide range of physiological functions, BSA has made it a model protein for biofunctionalization. BSA-coated AgNPs are being increasingly used in the recent past as sensors for environmental pollutants, targeted drug delivery, diagnostics, biosensors owing to exceptional biocompatibility, and optoelectronic properties. Besides functionalizing the nanoparticles for such uses, it highly stabilizes the nanoparticle, thereby preventing from aggregation and agglomeration, which is a major limitation for the application of nanoparticle in biological systems.
Principles and Role of BSA...
- Hansen UK (1981) Molecular aspects of ligand binding to serum albumin. Pharmacol Rev 33:17–53Google Scholar