Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Colloidal Silver Nanoparticles and Bovine Serum Albumin

  • Vinita Ernest
  • N. Chandrasekaran
  • Amitava Mukherjee
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_526

Synonyms

Definition

Purposely modified silver nanoparticles (AgNPs) using bovine serum albumin (BSA) is a biofunctionalization technique to obtain biocompatibility in metals where the surface of the metal nanoparticle is altered for various biomedical applications. Among the serum albumins, the most abundant proteins in plasma and with a wide range of physiological functions, BSA has made it a model protein for biofunctionalization. BSA-coated AgNPs are being increasingly used in the recent past as sensors for environmental pollutants, targeted drug delivery, diagnostics, biosensors owing to exceptional biocompatibility, and optoelectronic properties. Besides functionalizing the nanoparticles for such uses, it highly stabilizes the nanoparticle, thereby preventing from aggregation and agglomeration, which is a major limitation for the application of nanoparticle in biological systems.

Principles and Role of BSA...

This is a preview of subscription content, log in to check access

References

  1. Carter DD, Ho JX (1994) Structure of serum albumin. Adv Protein Chem 45:153–203CrossRefPubMedGoogle Scholar
  2. Di Marco M, Shamsuddin S, Razak KA, Aziz AA, Devaux C, Borghi E, Levy L, Sadun C (2010) Overview of the main methods used to combine proteins with nanosystems: absorption, bioconjugation, and encapsulation. Int J Nanomedicine 5:37–49PubMedGoogle Scholar
  3. Hansen UK (1981) Molecular aspects of ligand binding to serum albumin. Pharmacol Rev 33:17–53Google Scholar
  4. Mariam J, Dongre PM, Kothari DC (2011) Study of interaction of silver nanoparticles with bovine serum albumin using fluorescence spectroscopy. J Fluoresc 21:2193–2199CrossRefPubMedGoogle Scholar
  5. Nie S, Emory SR (1997) Probing single molecules and single nanoparticles by surface-enhanced Raman Scattering. Science 275:1102–1106CrossRefPubMedGoogle Scholar
  6. Olson RE, Christ DD (1996) Plasma protein binding of drugs. Annu Rep Med Chem 31:327–336CrossRefGoogle Scholar
  7. Ravindran A, Singh A, Raichur AM, Chandrasekaran N, Mukherjee A (2010) Studies on interaction of colloidal Ag nanoparticles with Bovine Serum Albumin (BSA). Colloids Surf B Biointerfaces 76:32–37CrossRefPubMedGoogle Scholar
  8. Sklar LA, Hudson BS, Simoni RD (1977) Conjugated polyene fatty acids as fluorescent probes: binding to bovine serum albumin. Biochemistry 16:5100–5108CrossRefPubMedGoogle Scholar
  9. Valanciunaite J, Bagdonas S, Streckyte G, Rotomskis R (2006) Spectroscopic study of TPPS4 nanostructures in the presence of bovine serum albumin. Photochem Photobiol Sci 5:381–388CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Vinita Ernest
    • 1
  • N. Chandrasekaran
    • 1
  • Amitava Mukherjee
    • 1
  1. 1.Centre for NanobiotechnologyVIT UniversityVelloreIndia