Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Selenium in Human Health and Disease

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_497



Selenium is a nonmetal trace element with atomic number 34 and atomic mass of 78.96. It is mostly found in nature as inorganic selenite, or organic amino acids selenomethionine and selenocysteine. Selenocysteine is present in the catalytic sites of selenoproteins. Humans have 25 selenoproteins. Most of the selenoproteins with identified function work as antioxidant enzymes, with the exception of the deiodinases, selenoprotein P, and selenophosphate synthethase 2, which regulate thyroid hormone levels, transport selenium through the bloodstream, and autoregulate the synthesis of selenoproteins themselves, respectively. Selenium and selenoproteins are implicated in several aspects of human health and disease, such as male fertility; neurological, endocrine, and immune function; and cancer. These implications have been widely studied and are discussed in this entry.



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  1. Berry MJ, Larsen PR (1992) The role of selenium in thyroid hormone action. Endocr Rev 13(2):207–219PubMedGoogle Scholar
  2. Davis CD, Tsuji PA et al (2012) Selenoproteins and cancer prevention. Annu Rev Nutr. [epub ahead of print]Google Scholar
  3. Fairweather-Tait SJ, Bao Y et al (2011) Selenium in human health and disease. Antioxid Redox Signal 14(7):1337–1383CrossRefPubMedGoogle Scholar
  4. Klein EA, Thompson IM Jr et al (2011) Vitamin E and the risk of prostate cancer: the selenium and vitamin E cancer prevention trial (SELECT). JAMA 306(14):1549–1556CrossRefPubMedGoogle Scholar
  5. Kryukov GV, Castellano S et al (2003) Characterization of mammalian selenoproteomes. Science 300(5624):1439–1443CrossRefPubMedGoogle Scholar
  6. Rayman MP (2012) Selenium and human health. Lancet 379(9822):1256–1268CrossRefPubMedGoogle Scholar
  7. Schweizer U, Dehina N et al (2011) Disorders of selenium metabolism and selenoprotein function. Curr Opin Pediatr 23(4):429–435CrossRefPubMedGoogle Scholar
  8. Stranges S, Marshall JR et al (2007) Effects of long-term selenium supplementation on the incidence of type 2 diabetes: a randomized trial. Ann Intern Med 147(4):217–223CrossRefPubMedGoogle Scholar
  9. Ursini F, Heim S et al (1999) Dual function of the selenoprotein PHGPx during sperm maturation. Science 285(5432):1393–1396CrossRefPubMedGoogle Scholar
  10. Yang GQ, Zhu LZ et al (1984) Human selenium requirements in China. In: Combs GF, Spallholz JE, Levander OA, Oldfield JE (eds) Selenium in biology and medicine. AVI Van Nostrand, New York, pp 589–607Google Scholar
  11. Yoo MH, Carlson BA et al (2012) Selenoproteins harboring a split personality in both preventing and promoting cancer. In: Hatfield DL, Berry MJ, Gladyshev VN (eds) Selenium: its molecular biology and role in human health. Springer, New YorkGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Cell & Molecular BiologyJohn A. Burns School of Medicine, University of Hawaii at ManoaHonoluluUSA