Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Selenium and Iodothyronine Deiodinases

  • Ulrich Schweizer
  • Doreen Braun
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_475



Deiodinases are enzymes capable of iodine elimination from iodothyronines. Iodothyronines are amino acid derivatives that are generated exclusively in the thyroid gland, where tyrosine residues in thyroglobulin are first iodinated at ring positions 3 and 5 and subsequently condensed via an ether bond. Iodothyronine molecules are proteolytically liberated from thyroglobulin and secreted. The major product of the thyroid gland, thyroxine, is a prohormone and needs conversion by 5′-deiodination to yield the nuclear receptor-activating triiodothyronine. Termination of iodothyronine action is achieved by 5-deiodination. In their catalytic centers,...

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Institute for Experimental Endocrinology, Charité-Universitätsmedizin BerlinBerlinGermany