Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Silicosis

  • Andrij Holian
  • Melisa Bunderson-Schelvan
  • Raymond F. HamiltonJr.
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_465

Synonyms

Definition

Silicosis is a debilitating and often life-threatening fibrotic disease resulting from exposure to crystalline silica. Silicosis is generally characterized by chronic inflammation and an aberrant fibrotic response to injury. In addition, a role for the matrix metalloproteinases in the etiology of silicosis has been suggested following the observation that MMP-2, -9, and -13 are upregulated in experimental lung silicosis (Perez-Ramos et al. 1999).

Silica and Silicosis

The dangers of silica exposure have been reported as far back as the ancient Greeks, particularly in relation to pulmonary disorders (Mason and Thompson 2010). While there are various forms of silica, the crystalline structure is known to be the most dangerous, as opposed to the amorphous form. It is also important to note that crystalline silica is the most common type involved in occupational exposures. In general, crystalline silica particles are...

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References

  1. Amalinei C, Caruntu ID et al (2010) Matrix metalloproteinases involvement in pathologic conditions. Rom J Morphol Embryol (Revue roumaine de morphologie et embryologie) 51(2):215–228Google Scholar
  2. Butler GS, Overall CM (2009) Updated biological roles for matrix metalloproteinases and new “intracellular” substrates revealed by degradomics. Biochemistry 48(46):10830–10845CrossRefPubMedGoogle Scholar
  3. Cassel SL, Eisenbarth SC et al (2008) The Nalp3 inflammasome is essential for the development of silicosis. Proc Natl Acad Sci USA 105(26):9035–9040CrossRefPubMedGoogle Scholar
  4. Cheng CY, Kuo CT et al (2010) IL-1beta induces expression of matrix metalloproteinase-9 and cell migration via a c-Src-dependent, growth factor receptor transactivation in A549 cells. Br J Pharmacol 160(7):1595–1610CrossRefPubMedGoogle Scholar
  5. Cohen RA, Patel A et al (2008) Lung disease caused by exposure to coal mine and silica dust. Semin Respir Crit Care Med 29(6):651–661CrossRefPubMedGoogle Scholar
  6. Crosby LM, Waters CM (2010) Epithelial repair mechanisms in the lung. Am J Physiol Lung Cell Mol Physiol 298(6):L715–731CrossRefPubMedGoogle Scholar
  7. Delgado L, Parra ER et al (2006) Apoptosis and extracellular matrix remodelling in human silicosis. Histopathology 49(3):283–289CrossRefPubMedGoogle Scholar
  8. Dostert C, Petrilli V et al (2008) Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 320(5876):674–677CrossRefPubMedGoogle Scholar
  9. Greenberg MI, Waksman J et al (2007) Silicosis: a review. Disease Month: DM 53(8):394–416CrossRefGoogle Scholar
  10. Hornung V, Bauernfeind F et al (2008) Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol 9(8):847–856CrossRefPubMedGoogle Scholar
  11. Ishihara Y, Nishikawa T et al (2003) Expression of matrix metalloproteinase, tissue inhibitors of metalloproteinase and adhesion molecules in silicotic mice with lung tumor metastasis. Toxicol Lett 142(1–2):71–75CrossRefPubMedGoogle Scholar
  12. Langley RJ, Mishra NC et al (2011) Fibrogenic and redox-related but not proinflammatory genes are upregulated in Lewis rat model of chronic silicosis. J Toxicol Environ Health A74(19):1261–1279CrossRefGoogle Scholar
  13. Mason E, Thompson SK (2010) A brief overview of crystalline silica. J Chem Health Safety 17:6–8CrossRefGoogle Scholar
  14. Olbruck H, Seemayer NH et al (1998) Supernatants from quartz dust treated human macrophages stimulate cell proliferation of different human lung cells as well as collagen-synthesis of human diploid lung fibroblasts in vitro. Toxicol Lett 96–97:85–95CrossRefPubMedGoogle Scholar
  15. Ortiz LA, Lasky J et al (2001) Tumor necrosis factor receptor deficiency alters matrix metalloproteinase 13/tissue inhibitor of metalloproteinase 1 expression in murine silicosis. Am J Respir Crit Care Med 163(1):244–252CrossRefPubMedGoogle Scholar
  16. OSHA. (2012) Safety and Health Topics: Silica, Crystalline. Retrieved 7 Apr 2012, from http://www.osha.gov/dsg/topics/silicacrystalline/index.html
  17. Pardo A, Perez-Ramos J et al (1999) Expression and localization of TIMP-1, TIMP-2, MMP-13, MMP-2, and MMP-9 in early and advanced experimental lung silicosis. Ann N Y Acad Sci 878:587–589CrossRefPubMedGoogle Scholar
  18. Perdereau C, Godat E et al (2006) Cysteine cathepsins in human silicotic bronchoalveolar lavage fluids. Biochim Biophys Acta 1762(3):351–356CrossRefPubMedGoogle Scholar
  19. Perez-Ramos J, de Lourdes Segura-Valdez M et al (1999) Matrix metalloproteinases 2, 9, and 13, and tissue inhibitors of metalloproteinases 1 and 2 in experimental lung silicosis. Am J Respir Crit Care Med 160(4):1274–1282CrossRefPubMedGoogle Scholar
  20. Piguet PF, Collart MA et al (1990) Requirement of tumour necrosis factor for development of silica-induced pulmonary fibrosis. Nature 344(6263):245–247CrossRefPubMedGoogle Scholar
  21. Rodriguez D, Morrison CJ et al (2010) Matrix metalloproteinases: what do they not do? New substrates and biological roles identified by murine models and proteomics. Biochim Biophys Acta 1803(1):39–54CrossRefPubMedGoogle Scholar
  22. Sbardella D, Fasciglione GF et al (2012) Human matrix metalloproteinases: an ubiquitarian class of enzymes involved in several pathological processes. Mol Aspects Med 33(2):119–208CrossRefPubMedGoogle Scholar
  23. Scabilloni JF, Wang L et al (2005) Matrix metalloproteinase induction in fibrosis and fibrotic nodule formation due to silica inhalation. Am J Physiol Lung Cell Mol Physiol 288(4):L709–717CrossRefPubMedGoogle Scholar
  24. Shapiro SD (1998) Matrix metalloproteinase degradation of extracellular matrix: biological consequences. Curr Opin Cell Biol 10(5):602–608CrossRefPubMedGoogle Scholar
  25. Shapiro SD, Senior RM (1999) Matrix metalloproteinases. Matrix degradation and more. Am J Respir Cell Mol Biol 20(6):1100–1102CrossRefPubMedGoogle Scholar
  26. Wynn TA, Barron L (2010) Macrophages: master regulators of inflammation and fibrosis. Semin Liver Dis 30(3):245–257CrossRefPubMedGoogle Scholar
  27. Yatera K, Morimoto Y et al (2001) Increased expression of matrix metalloproteinase in Clara cell-ablated mice inhaling crystalline silica. Environ Health Perspect 109(8):795–799CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Andrij Holian
    • 1
  • Melisa Bunderson-Schelvan
    • 1
  • Raymond F. HamiltonJr.
    • 1
  1. 1.Department of Biomedical and Pharmaceutical Sciences, Center for Environmental HealthThe University of MontanaMissoulaUSA