Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Selenophosphate Synthetase

  • Nicholas Noinaj
  • Susan K. Buchanan
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_458



Selenophosphate synthetase is an enzyme that catalyzes the formation of selenophosphate, the selenium donor in the biosynthesis of the amino acid selenocysteine.

Selenophosphate synthetase (SPS) is a metalloprotein responsible for catalyzing the formation of selenophosphate, a selenium-containing precursor utilized in the biosynthesis of selenocysteine, commonly referred to as the 21st amino acid.

Newly synthesized proteins that carry a seleno-modified amino acid such as selenocysteine or selenomethionine are often termed selenoproteins (Rother et al. 2001). Examples include the enzymes thioredoxin reductase and glutathione peroxidase, both of which act as antioxidants for the clearance of potentially harmful reactive oxygen species. Selenoproteins can be found in many organisms from bacteria to humans and are expressed in many tissues within the human body. Mutations in genes for...

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Laboratory of Molecular BiologyNational Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of HealthBethesdaUSA