Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Selenium-Binding Protein 1 and Cancer

  • Cunxian Zhang
  • Xudong Wang
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_455



Selenium-binding protein 1 is an intracellular protein that binds selenium covalently and is thought to mediate the actions of selenium. Cancer is any malignant growth or tumor characterized by abnormal and uncontrolled proliferation of neoplastic cells that disrupt adjacent tissue and have the capacity of spreading to other parts of the body through lymphatic vessels or blood stream.

Selenium and Selenium-Containing Proteins

Selenium is an essential trace mineral with a potent anticancer effect. Epidemiological studies have shown a correlation between high cancer rates and low dietary selenium intake (Klein 2004). The relationship of selenium with cancer was further demonstrated by clinical trials revealing an effect of dietary selenium supplementation on the reduction of total cancer mortality, total cancer incidence, and incidences of prostate, lung, colorectal, and skin cancers. The proposed mechanisms...

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of PathologyWomen & Infants Hospital of Rhode Island, Kent Memorial Hospital, Warren Alpert Medical School of Brown UniversityProvidenceUSA
  2. 2.Department of PathologySt Vincent HospitalWorcesterUSA