Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Selenium-Binding Protein 1 and Cancer

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_455

Synonyms

Definitions

Selenium-binding protein 1 is an intracellular protein that binds selenium covalently and is thought to mediate the actions of selenium. Cancer is any malignant growth or tumor characterized by abnormal and uncontrolled proliferation of neoplastic cells that disrupt adjacent tissue and have the capacity of spreading to other parts of the body through lymphatic vessels or blood stream.

Selenium and Selenium-Containing Proteins

Selenium is an essential trace mineral with a potent anticancer effect. Epidemiological studies have shown a correlation between high cancer rates and low dietary selenium intake (Klein 2004). The relationship of selenium with cancer was further demonstrated by clinical trials revealing an effect of dietary selenium supplementation on the reduction of total cancer mortality, total cancer incidence, and incidences of prostate, lung, colorectal, and skin cancers. The proposed mechanisms...

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References

  1. Brown LM, Helmke SM, Hunsucker SW, Netea-Maier RT, Chiang SA, Heinz DE, Shroyer KR, Duncan MW, Haugen BR (2006) Quantitative and qualitative differences in protein expression between papillary thyroid carcinoma and normal thyroid tissue. Mol Carcinog 45:613–626CrossRefPubMedGoogle Scholar
  2. Chang PWG, Tsui SKW, Liew CC, Lee CY, Waye MMY, Fung KP (1997) Isolation, characterization, and chromosomal mapping of a novel cDNA clone encoding human selenium binding protein. J Cell Biochem 64:217–224CrossRefPubMedGoogle Scholar
  3. Chen G, Wang H, Miller CT, Thomas DG, Gharib TG, Misek DE, Giordano TJ, Orringer MB, Hanash SM, Beer DG (2004) Reduced selenium-binding protein 1 expression is associated with poor outcome in lung adenocarcinomas. J Pathol 202:321–329CrossRefPubMedGoogle Scholar
  4. Gladyshev VN (2006) Selenoproteins and selenoproteomes. In: Hatfield DL, Berry MJ, Gladyshev VN (eds) Selenium: its molecular biology and role in human health, 2nd edn. Springer Science + Business Media LLC, Philadelphia, pp 99–114Google Scholar
  5. Huang KC, Park DC, Ng SK, Lee JY, Ne X, Ng WC, Bandera CA, Welch WR, Berkowitz RS, Mok SC, Ng SW (2006) Selenium binding protein 1 in ovarian cancer. Int J Cancer 118:2433–2440CrossRefPubMedGoogle Scholar
  6. Klein EA (2004) Selenium: epidemiology and basic science. J Urol 171:S50–S53CrossRefPubMedGoogle Scholar
  7. Li T, Yang W, Li M, Byun D, Tong C, Nasser S, Zhuang M, Arango D, Mariadason JM, Augenlicht LH (2008) Expression of selenium-binding protein 1 characterizes intestinal cell maturation and predicts survival for patients with colorectal cancer. Mol Nutr Food Res 52:1289–1299CrossRefPubMedGoogle Scholar
  8. Pass HI, Liu Z, Wali A, Bueno R, Land S, Lott D, Siddiq F, Lonardo F, Carbone M, Draghici S (2004) Gene expression profiles predict survival and progression of pleural mesothelioma. Clin Cancer Res 10:849–859CrossRefPubMedGoogle Scholar
  9. Pohl NM, Tong C, Fang W, Bi X, Li T, Yang W (2009) Transcriptional regulation and biological functions of selenium-binding protein 1 in colorectal cancer in vitro and in nude mouse xenografts. PLoS One 4:e7774CrossRefPubMedGoogle Scholar
  10. Raucci R, Colonna G, Guerriero E, Capone F, Accardo M, Castello G, Costantini S (2011) Structural and functional studies of the human selenium binding protein-1 and its involvement in hepatocellular carcinoma. Biochim Biophys Acta 1814:513–522CrossRefPubMedGoogle Scholar
  11. Silvers AL, Lin L, Bass AJ, Chen G, Wang Z, Thomas DG, Lin J, Giordano TJ, Orringer MB, Beer DG, Chang AC (2010) Decreased selenium-binding protein 1 in esophageal adenocarcinoma results from posttranscriptional and epigenetic regulation and affects chemosensitivity. Clin Cancer Res 16:2009–2021CrossRefPubMedGoogle Scholar
  12. Stammer K, Edassery SL, Barua A, Bitterman P, Bahr JM, Hales DB, Luborsky JL (2008) Selenium-binding protein 1 expression in ovaries and ovarian tumors in the laying hen, a spontaneous model of human ovarian cancer. Gynecol Oncol 109:115–121CrossRefPubMedGoogle Scholar
  13. Xia YJ, Ma YY, He XJ, Wang HJ, Ye ZY, Tao HQ (2011) Suppression of selenium-binding protein 1 in gastric cancer is associated with poor survival. Hum Pathol 42:1620–1628CrossRefPubMedGoogle Scholar
  14. Yang M, Sytkowski AJ (1998) Differential expression and androgen regulation of the human selenium-binding protein gene HSP56 in prostate cancer cells. Cancer Res 58:3150–3153PubMedGoogle Scholar
  15. Zhang C, Wang YE, Zhang P, Liu F, Sung CJ, Steinhoff MM, Quddus MR, Lawrence WD (2010a) Progressive loss of selenium-binding protein 1 expression correlates with increasing epithelial proliferation and papillary complexity in ovarian serous borderline tumor and low-grade serous carcinoma. Hum Pathol 41:255–261CrossRefPubMedGoogle Scholar
  16. Zhang P, Zhang C, Wang X, Liu F, Sung CJ, Quddus MR, Lawrence WD (2010b) The expression of selenium-binding protein 1 is decreased in uterine leiomyoma. Diag Pathol 5:80CrossRefGoogle Scholar
  17. Zhang J, Zhan N, Dong WG (2011) Altered expression of selenium-binding protein 1 in gastric carcinoma and precursor lesions. Med Oncol 28:951–957CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of PathologyWomen & Infants Hospital of Rhode Island, Kent Memorial Hospital, Warren Alpert Medical School of Brown UniversityProvidenceUSA
  2. 2.Department of PathologySt Vincent HospitalWorcesterUSA