Selenium and Glutathione Peroxidases
Selenium-containing Glutathione Peroxidases constitute a family of enzymes that carry a selenocysteine residue in their polypeptide chain and that catalyze the reduction of hydroperoxides to the corresponding alcohols at the expense of reduced glutathione.
About 30 years ago in 1982, Ursini and his colleagues identified a protein factor that prevented lipid peroxidation in the presence of glutathione. In the following years, it was established that this protein termed phospholipid hydroperoxide glutathione peroxidase (phGPx) contains selenium in equimolar amounts (Ufer and Wang 2011). By today, a whole family of Glutathione Peroxidases (GPx; EC 188.8.131.52) has been characterized comprising of at least eight known isoforms in mammals. Some of these GPx family members are selenium-dependent, whereas other enzymes of the GPx family do not contain selenium (Herbette et...