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Selenium and Muscle Function

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Synonyms

Cardiovascular disorders; Cardiomyopathy; Chagas disease; Exudative diathesis; Keshan disease; Mallory Body-like Desmin-Related Myopathy (MB-DRM); Multiminicore disease (MmD); Myopathy with Congenital Fiber Type Disproportion (CFTD); Myotonic dystrophies; Nutritional muscular dystrophy; Rigid lamb syndrome; Rigid Spine Muscular Dystrophy (RSMD1); Selenoprotein 15 kDa (Sep15); Selenoprotein K (SelK); Selenoprotein N (SelN, SepN); Selenoprotein S (SelS); Selenoprotein T (SelT); SEPN1 gene; SEPN1-related myopathies (SEPN1-RM); White muscle disease

Definition

Selenium deficiencies have been linked to different forms of cardiac and skeletal muscle diseases in human and livestock, and selenium supplementation has been proved to be protective against the emergence of these disorders. Selenium is incorporated as selenocysteine into several enzymes that play a critical role in oxidative-reduction homeostasis. Several of these enzymes are supposed to play important function for muscle...

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References

  • Arbogast S, Ferreiro A (2010) Selenoproteins and protection against oxidative stress: selenoprotein N as a novel player at the crossroads of redox signaling and calcium homeostasis. Antioxid Redox Signal 12:893–904

    Article  CAS  PubMed  Google Scholar 

  • Beck MA (2007) Selenium and vitamin E status: impact on viral pathogenicity. J Nutr 137:1338–1340

    CAS  PubMed  Google Scholar 

  • Bellinger FP, Raman AV, Reeves MA, Berry MJ (2009) Regulation and function of selenoproteins in human disease. Biochem J 422:11–22

    Article  CAS  PubMed  Google Scholar 

  • Castets P, Lescure A, Guicheney P, Allamand V (2012) Selenoprotein N in skeletal muscle: from diseases to function. J Mol Med (Berl) [Epub ahead of print]

    Google Scholar 

  • Chariot P, Bignani O (2003) Skeletal muscle disorders associated with selenium deficiency in humans. Muscle Nerve 27:662–668

    Article  CAS  PubMed  Google Scholar 

  • de Lorgeril M, Salen P (2006) Selenium and antioxidant defenses as major mediators in the development of chronic heart failure. Heart Fail Rev 11:13–17

    Article  CAS  PubMed  Google Scholar 

  • Jelicks LA, de Souza AP, Araújo-Jorge TC, Tanowitz HB (2011) Would selenium supplementation aid in therapy for chagas disease? Trends Parasitol 27:102–105

    Article  CAS  PubMed  Google Scholar 

  • Juniper DT, Phipps RH, Bertin G (2011) Effect of dietary supplementation with selenium-enriched yeast or sodium selenite on selenium tissue distribution and meat quality in commercial-line turkeys. Animal 5:1751–1760

    Article  CAS  PubMed  Google Scholar 

  • Lescure A, Gautheret D, Carbon P, Krol A (1999) Novel selenoproteins identified in silico and in vivo by using a conserved RNA structural motif. J Biol Chem 274:38147–38154

    Article  CAS  PubMed  Google Scholar 

  • Moghadaszadeh B, Petit N, Jaillard C et al (2001) Mutations in SEPN1 cause congenital muscular dystrophy with spinal rigidity and restrictive respiratory syndrome. Nat Genet 29:17–18

    Article  CAS  PubMed  Google Scholar 

  • Oldfield J (1987) The two faces of selenium. J Nutr 117:2002–2008

    CAS  PubMed  Google Scholar 

  • Rederstorff M, Krol A, Lescure A (2006) Understanding the importance of selenium and selenoproteins in muscle function. Cell Mol Life Sci 63:52–59

    Article  CAS  PubMed  Google Scholar 

  • Surai PF (2002) Selenium in poultry nutrition 1. Antioxidant properties, deficiency and toxicity. Worlds Poult Sci J 58:333–347

    Article  Google Scholar 

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Correspondence to Alain Lescure .

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© 2013 Springer Science+Business Media New York

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Lescure, A., Briens, M. (2013). Selenium and Muscle Function. In: Kretsinger, R.H., Uversky, V.N., Permyakov, E.A. (eds) Encyclopedia of Metalloproteins. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1533-6_452

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