Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Selenium and Muscle Function

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_452



Selenium deficiencies have been linked to different forms of cardiac and skeletal muscle diseases in human and livestock, and selenium supplementation has been proved to be protective against the emergence of these disorders. Selenium is incorporated as selenocysteine into several enzymes that play a critical role in oxidative-reduction homeostasis. Several of these enzymes are supposed to play important...

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  1. Arbogast S, Ferreiro A (2010) Selenoproteins and protection against oxidative stress: selenoprotein N as a novel player at the crossroads of redox signaling and calcium homeostasis. Antioxid Redox Signal 12:893–904CrossRefPubMedGoogle Scholar
  2. Beck MA (2007) Selenium and vitamin E status: impact on viral pathogenicity. J Nutr 137:1338–1340PubMedGoogle Scholar
  3. Bellinger FP, Raman AV, Reeves MA, Berry MJ (2009) Regulation and function of selenoproteins in human disease. Biochem J 422:11–22CrossRefPubMedGoogle Scholar
  4. Castets P, Lescure A, Guicheney P, Allamand V (2012) Selenoprotein N in skeletal muscle: from diseases to function. J Mol Med (Berl) [Epub ahead of print]Google Scholar
  5. Chariot P, Bignani O (2003) Skeletal muscle disorders associated with selenium deficiency in humans. Muscle Nerve 27:662–668CrossRefPubMedGoogle Scholar
  6. de Lorgeril M, Salen P (2006) Selenium and antioxidant defenses as major mediators in the development of chronic heart failure. Heart Fail Rev 11:13–17CrossRefPubMedGoogle Scholar
  7. Jelicks LA, de Souza AP, Araújo-Jorge TC, Tanowitz HB (2011) Would selenium supplementation aid in therapy for chagas disease? Trends Parasitol 27:102–105CrossRefPubMedGoogle Scholar
  8. Juniper DT, Phipps RH, Bertin G (2011) Effect of dietary supplementation with selenium-enriched yeast or sodium selenite on selenium tissue distribution and meat quality in commercial-line turkeys. Animal 5:1751–1760CrossRefPubMedGoogle Scholar
  9. Lescure A, Gautheret D, Carbon P, Krol A (1999) Novel selenoproteins identified in silico and in vivo by using a conserved RNA structural motif. J Biol Chem 274:38147–38154CrossRefPubMedGoogle Scholar
  10. Moghadaszadeh B, Petit N, Jaillard C et al (2001) Mutations in SEPN1 cause congenital muscular dystrophy with spinal rigidity and restrictive respiratory syndrome. Nat Genet 29:17–18CrossRefPubMedGoogle Scholar
  11. Oldfield J (1987) The two faces of selenium. J Nutr 117:2002–2008PubMedGoogle Scholar
  12. Rederstorff M, Krol A, Lescure A (2006) Understanding the importance of selenium and selenoproteins in muscle function. Cell Mol Life Sci 63:52–59CrossRefPubMedGoogle Scholar
  13. Surai PF (2002) Selenium in poultry nutrition 1. Antioxidant properties, deficiency and toxicity. Worlds Poult Sci J 58:333–347CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.UPR ARN du CNRS, Université de Strasbourg, Institut de Biologie Moléculaire et CellulaireStrasbourgFrance