Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Silica, Immunological Effects

  • Naoko Kumagai-Takei
  • Suni Lee
  • Hidenori Matsuzaki
  • Hiroaki Hayashi
  • Megumi Maeda
  • Yasumitsu Nishimura
  • Takemi Otsuki
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_445

Synonyms

Definition

Patients with silicosis suffer from lung fibrosis causing respiratory dyspnea, complicated chronic bronchitis, pulmonary tuberculosis, emphysema, and other pulmonary diseases and are often complicated by autoimmune/collagen diseases such as RA (rheumatoid arthritis, well known as Caplan syndrome), SLE (systemic lupus erythematosus), SSc (systemic sclerosis), and ANCA (anti-neutrophil cytoplasmic autoantibody)-related vasculitis/nephritis. It had previously been considered that dysregulation of autoimmunity caused by silica exposure was induced by an adjuvant effect of silica. However, recent developments in immunology have provided new concepts such as recognition of the danger signal by the NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin-domain-containing 3, Nalp3) inflammasome in antigen-presenting cells, alteration of the CD95/Fas molecule...

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References

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Naoko Kumagai-Takei
    • 1
  • Suni Lee
    • 1
  • Hidenori Matsuzaki
    • 1
  • Hiroaki Hayashi
    • 2
  • Megumi Maeda
    • 3
  • Yasumitsu Nishimura
    • 1
  • Takemi Otsuki
    • 1
  1. 1.Department of HygieneKawasaki Medical SchoolOkayamaJapan
  2. 2.Department of DermatologyKawasaki Medical SchoolKurashikiJapan
  3. 3.Department of Biofunctional Chemistry, Division of BioscienceOkayama University Graduate School of Natural Science and TechnologyOkayamaJapan