Amine-boranes are complexes of a Lewis acid borane (e.g., BH3, BH2CN, BH2COOH, BH2COOCH3, BH2CONHCH2CH3) and an amine (e.g., R,R′,R″N) where the lone electron pair on the nitrogen atom forms a coordinate covalent bond by donating both of its electrons into the vacant orbital of borane.
Chemistry of Boron
Boron is in column three of the periodic table and has three valence electrons. This leaves the boron atom with a vacant orbital capable of accepting a pair of electrons acting as a Lewis acid. Typically, molecules with atoms containing lone pairs of electrons will form complexes with boron such as nitrogen, oxygen, and phosphorus (Spielvogel 1988).
When coordinated to amino groups, the borane becomes tetrahedral making it isosteric to a tetrahedral carbon atom. Since the borane is more...
- Soloway A, Barth R, Carpenter D (eds) (1993) Advances in neutron capture therapy. Springer, New YorkGoogle Scholar
- Spielvogel B (1988) Pharmacologically active boron analogues of amino acids. In: Liebman J, Greenberg A (eds) Advances in boron and the boranes. VCH Publishers, New YorkGoogle Scholar
- Spielvogel B, Sood A, Shaw B et al (1992) In: Allen B et al (eds) Progress in neutron capture therapy for cancer. Springer, New YorkGoogle Scholar