Synonyms
Proteins: sarco(endo)plasmic reticulum Ca2+-ATPase, SERCA; Plasma membrane Ca2+-ATPase (PMCA).
DNA: ATP2A1-3 (human genes for SERCA1-3); ATP2B1-4 (PMCA1-4)
Biological functions: Ca2+-pump; Ca2+-translocating ATPase
Definition
Enzyme, EC 3.6.3.8; an ATP-powered ion pump that transports Ca2+ across the membrane against a large (up to 15,000-fold) concentration gradient. A representative member of the P-type ATPase family, which is in turn a member of the haloacid dehalogenase superfamily (Burroughs et al. 2006). EC 3.6.3.8 includes sarco(endo)plasmic reticulum calcium ATPase, commonly abbreviated as SERCA, and plasma membrane Ca2+-ATPase, abbreviated as PMCA. As SERCA transports 2 Ca2+ ions per ATP hydrolyzed from the cytoplasm into the lumen of sarcoplasmic reticulum and 2 or 3 H+ in the opposite direction, it may be termed “Ca2+, H+-ATPase,” similarly to Na+, K+-ATPase. PMCA transports one Ca2+ per ATP.
Biological Function and Amino Acid Sequence Information
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References
Brini M, Carafoli E (2009) Calcium pumps in health and disease. Physiol Rev 89:1341–1378
Burroughs AM, Allen KN, Dunaway-Mariano D, Aravind L (2006) Evolutionary genomics of the HAD superfamily: understanding the structural adaptations and catalytic diversity in a superfamily of phosphoesterases and allied enzymes. J Mol Biol 361:1003–1034
Inesi G (1985) Mechanism of calcium transport. Annu Rev Physiol 47:573–601
MacLennan DH, Kranias EG (2003) Phospholamban: a crucial regulator of cardiac contractility. Nat Rev Mol Cell Biol 4:566–577
Toyoshima C (2008) Structural aspects of ion pumping by Ca2+-ATPase of sarcoplasmic reticulum. Arch Biochem Biophys 476:3–11
Vangheluwe P, Sepulveda MR, Missiaen L, Raeymaekers L, Wuytack F, Vanoevelen J (2009) Intracellular Ca2+- and Mn2+-transport ATPases. Chem Rev 109:4733–4759
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Toyoshima, C. (2013). Calcium ATPases. In: Kretsinger, R.H., Uversky, V.N., Permyakov, E.A. (eds) Encyclopedia of Metalloproteins. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1533-6_44
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DOI: https://doi.org/10.1007/978-1-4614-1533-6_44
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