Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Calcium ATPases

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_44



Enzyme, EC; an ATP-powered ion pump that transports Ca2+ across the membrane against a large (up to 15,000-fold) concentration gradient. A representative member of the P-type ATPase family, which is in turn a member of the haloacid dehalogenase superfamily (Burroughs et al. 2006). EC includes sarco(endo)plasmic reticulum calcium ATPase, commonly abbreviated as SERCA, and plasma membrane Ca2+-ATPase, abbreviated as PMCA. As SERCA transports 2 Ca2+ ions per ATP hydrolyzed from the cytoplasm into the lumen of sarcoplasmic reticulum and 2 or 3 H+ in the opposite direction, it may be termed “Ca2+, H+-ATPase,” similarly to Na+, K+-ATPase. PMCA transports one Ca2+ per ATP.

Biological Function and Amino Acid Sequence Information

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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Institute of Molecular and Cellular BiosciencesThe University of TokyoTokyoJapan