Synonyms
Cadherin family members in embryonic development, morphogenesis, and disease; Cadherins, protocadherins, and cadherin-related proteins; Calcium-dependent cell–cell adhesion proteins; Signaling by cadherins and cadherin-associated proteins; Structures and functions of extracellular calcium-binding cadherin repeats
Definitions
Genuine cadherins are metazoa-specific, calcium-dependent transmembrane (TM) proteins that generally mediate cell–cell adhesion or cell–cell recognition and are characterized by the presence of at least two consecutive extracellular cadherin-specific motifs in their extracellular domains. Each motif, called a cadherin repeat (EC), is about 110 amino acid residues (AA) long and comprises highly conserved calcium-binding AA.
All members of the major cadherin (CDH) gene family encode proteins with an ectodomain comprising at least five consecutive calcium-binding ECs. There is strong sequence conservation within the family. The family includes the...
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Brigidi GS, Bamji SX (2011) Cadherin-catenin adhesion complexes at the synapse. Curr Opin Neurobiol 21(2):208–214
Elledge HM, Kazmierczak P, Clark P et al (2010) Structure of the N terminus of cadherin 23 reveals a new adhesion mechanism for a subset of cadherin superfamily members. Proc Natl Acad Sci USA 107:10708–10712
Harris TJ, Tepass U (2010) Adherens junctions: from molecules to morphogenesis. Nat Rev Mol Cell Biol 11:502–514
Harrison OJ, Jin X, Hong S et al (2011) The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins. Structure 19:244–256
Hulpiau P, van Roy F (2009) Molecular evolution of the cadherin superfamily. Int J Biochem Cell Biol 41:343–369
Morishita H, Yagi T (2007) Protocadherin family: diversity, structure, and function. Curr Opin Cell Biol 19:584–592
Nelson WJ, Fuchs E (eds) (2010) Cell-cell junctions, Cold Spring Harbor perspectives in biology. Cold Spring Harbor Laboratory Press, Woodbury
Nishimura T, Takeichi M (2009) Remodeling of the adherens junctions during morphogenesis. Curr Top Dev Biol 89:33–54
Redies C, Vanhalst K, van Roy F (2005) Delta-protocadherins: unique structures and functions. Cell Mol Life Sci 62:2840–2852
van Roy F, Berx G (2008) The cell-cell adhesion molecule E-cadherin. Cell Mol Life Sci 65:3756–3788
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Hulpiau, P., van Roy, F. (2013). Cadherins. In: Kretsinger, R.H., Uversky, V.N., Permyakov, E.A. (eds) Encyclopedia of Metalloproteins. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1533-6_40
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DOI: https://doi.org/10.1007/978-1-4614-1533-6_40
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-1532-9
Online ISBN: 978-1-4614-1533-6
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