Cadherin family members in embryonic development, morphogenesis, and disease; Cadherins, protocadherins, and cadherin-related proteins; Calcium-dependent cell–cell adhesion proteins; Signaling by cadherins and cadherin-associated proteins; Structures and functions of extracellular calcium-binding cadherin repeats
Genuine cadherins are metazoa-specific, calcium-dependent transmembrane (TM) proteins that generally mediate cell–cell adhesion or cell–cell recognition and are characterized by the presence of at least two consecutive extracellular cadherin-specific motifs in their extracellular domains. Each motif, called a cadherin repeat (EC), is about 110 amino acid residues (AA) long and comprises highly conserved calcium-binding AA.
All members of the major cadherin (CDH) gene family encode proteins with an ectodomain comprising at least five consecutive calcium-binding ECs. There is strong sequence conservation within the family. The family includes the...
- Nelson WJ, Fuchs E (eds) (2010) Cell-cell junctions, Cold Spring Harbor perspectives in biology. Cold Spring Harbor Laboratory Press, WoodburyGoogle Scholar