Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov


Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_40



Genuine cadherins are metazoa-specific, calcium-dependent transmembrane (TM) proteins that generally mediate cell–cell adhesion or cell–cell recognition and are characterized by the presence of at least two consecutive extracellular cadherin-specific motifs in their extracellular domains. Each motif, called a cadherin repeat (EC), is about 110 amino acid residues (AA) long and comprises highly conserved calcium-binding AA.

All members of the major cadherin (CDH) gene family encode proteins with an ectodomain comprising at least five consecutive calcium-binding ECs. There is strong sequence conservation within the family. The family includes the...

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department for Molecular Biomedical ResearchVIBGhentBelgium
  2. 2.Department of Biomedical Molecular BiologyGhent UniversityGhentBelgium