Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

C2 Domain Proteins

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_39



C2 domain proteins are proteins containing the second conserved domain of protein kinase C. The C2 domain is an all-beta domain, consisting of a beta-sandwich of two antiparallel four-stranded beta sheets. C2 domains are found in a wide range of both enzymatic and non-enzymatic proteins involved in signal transduction and membrane trafficking.


Comprising approximately 130 amino acids, the C2 domain was first identified as a conserved domain of the calcium-dependent protein kinases C (PKC). 233 C2 domains are predicted in 127 human proteins, making the C2 domain, after the pleckstrin homology (PH) domain, the second most abundant lipid-binding domain found in eukaryotic proteins. Since...

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Max F. Perutz LaboratoriesViennaAustria