C2 Domain Proteins
C2 domain proteins are proteins containing the second conserved domain of protein kinase C. The C2 domain is an all-beta domain, consisting of a beta-sandwich of two antiparallel four-stranded beta sheets. C2 domains are found in a wide range of both enzymatic and non-enzymatic proteins involved in signal transduction and membrane trafficking.
Comprising approximately 130 amino acids, the C2 domain was first identified as a conserved domain of the calcium-dependent protein kinases C (PKC). 233 C2 domains are predicted in 127 human proteins, making the C2 domain, after the pleckstrin homology (PH) domain, the second most abundant lipid-binding domain found in eukaryotic proteins. Since...