Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Calbindin D28k

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_37

Synonyms

Definitions

EF-hand: helix-loop-helix motif obeying a 29-residue consensus sequence with hydrophobic and Ca2+-ligating residues in defined positions, typically forming a pentagonal bipyramidal coordination sphere.

Hexa EF-hand (HEF) proteins: Ca2+-binding proteins containing six EF-hand motifs.

Domain: Independent folding unit.

Subdomain: Super-secondary motif which is part of a domain.

Deamidation: Spontaneous hydrolysis of a carboxamide to a carboxylic acid via a cyclic intermediate. Deamidation of asparagine typically leads to iso-aspartate and aspartate in a 2:1 molar ratio.

Chromophoric chelator: Metal-binding dye which changes its optical spectrum upon chelation.

Discovery and Prevalence

Calbindin D28k was originally purified from chicken intestine (Wasserman and Taylor 1996)...

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References

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of ChemistryHaverford CollegeHaverfordUSA
  2. 2.Department of Biochemistry and Structural BiologyLund University, Chemical CentreLundSweden