Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Calcium Ion Selectivity in Biological Systems

  • Todor Dudev
  • Carmay Lim
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_36



Metal selectivity of a  Ca2+-binding site is an outcome of the competition between the bulk solvent and the protein ligands for the “native” Ca 2+ and a “rival” cation M q+ (M = Na, K, Mg, Ln, etc.; q = 1, 2, 3) and can be assessed by the free energy of the M q+ → Ca 2+ exchange reaction:
$$\eqalign{ {(}{{\rm{M}}^{{{\rm{q + }}}}}{\rm{ - aq) + (C}}{{\rm{a}}^{{{2 + }}}}{\rm{ - protein) }} \to \cr \quad{ (}{{\rm{M}}^{{{\rm{q + }}}}}{\rm{ - protein) + (C}}{{\rm{a}}^{{{2 + }}}}{\rm{ - aq)}}} $$
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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Institute of Biomedical Sciences, Academia SinicaTaipeiTaiwan
  2. 2.Department of ChemistryNational Tsing Hua UniversityHsinchuTaiwan