Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Calcium Ion Selectivity in Biological Systems

  • Todor Dudev
  • Carmay Lim
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_36

Synonyms

Background/Definitions

Metal selectivity of a  Ca2+-binding site is an outcome of the competition between the bulk solvent and the protein ligands for the “native” Ca 2+ and a “rival” cation M q+ (M = Na, K, Mg, Ln, etc.; q = 1, 2, 3) and can be assessed by the free energy of the M q+ → Ca 2+ exchange reaction:
$$\eqalign{ {(}{{\rm{M}}^{{{\rm{q + }}}}}{\rm{ - aq) + (C}}{{\rm{a}}^{{{2 + }}}}{\rm{ - protein) }} \to \cr \quad{ (}{{\rm{M}}^{{{\rm{q + }}}}}{\rm{ - protein) + (C}}{{\rm{a}}^{{{2 + }}}}{\rm{ - aq)}}} $$
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References

  1. Drake SK, Lee KL, Falke JJ (1996) Tuning the equilibrium ion affinity and selectivity of the EF-hand calcium binding motif: substitutions at the gateway position. Biochemistry 35:6697–6705CrossRefPubMedGoogle Scholar
  2. Dudev T, Lim C (2003) Principles governing Mg, Ca, and Zn binding and selectivity in proteins. Chem Rev 103:773–787CrossRefPubMedGoogle Scholar
  3. Gifford JL, Walsh MP, Vogel HJ (2007) Structures and metal-ion-binding properties of Ca2+-binding helix-loop-helix EF-hand motifs. Biochem J 405:199–221CrossRefPubMedGoogle Scholar
  4. Gillespie D, Fill M (2008) Intracellular calcium release channels mediate their own countercurrent: the ryanodine receptor case study. Biophys J 95:3706–3714CrossRefPubMedGoogle Scholar
  5. Hille B (1992) Ionic channels of excitable membranes, 2nd edn. Sinauer Associates, SunderlandGoogle Scholar
  6. Nalefski EA, Falke JJ (1996) The C2 domain calcium-binding motif: structural and functional diversity. Protein Sci 5:2375–2390CrossRefPubMedGoogle Scholar
  7. Nalefski EA, Falke JJ (2002) Cation charge and size selectivity of the C2 domain of cytosolic phospholipase A2. Biochemistry 41:1109–1122CrossRefPubMedGoogle Scholar
  8. Shikamoto Y, Morita T, Fujimoto Z, Mizuno H (2003) Crystal structure of Mg2+ and Ca2+-bound Gla domain of factor IX complexed with binding protein. J Biol Chem 278:24090–24094CrossRefPubMedGoogle Scholar
  9. Stenflo J, Suttie JW (1977) Vitamin K – dependent formation of gamma-carboxyglutamic acid. Annu Rev Biochem 46:157–172CrossRefPubMedGoogle Scholar
  10. Tinker A, Lindsay ARG, Williams AJ (1992) A model for ionic conduction in the ryanodyne receptor channel of sheep cardiac muscle sarcoplasmic reticulum. J Gen Physiol 100:495–517CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Institute of Biomedical Sciences, Academia SinicaTaipeiTaiwan
  2. 2.Department of ChemistryNational Tsing Hua UniversityHsinchuTaiwan