Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Calcium-Binding Protein Site Types

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_35

Synonyms

Calcium:  Ca2+;  Ca(II); Chelate:  Bind;  Coordinate

Definitions

Calcium: A soft gray alkaline earth metal. Ionic calcium (Ca2+) is essential for numerous cellular functions, as well as biomineralization.

Calcium-binding protein: Any protein or enzyme that requires the binding of a calcium ion to fulfill either a functional or structural role.

Binding site: Region in the protein where metal ions will bind as a result of electrostatic interactions with ligands of opposite charge.

Ligand: Ion, atom, or molecule that binds to a metal ion to form a coordination complex.

Tertiary structure: Three-dimensional shape of a protein, enzyme, or molecule.

Diverse Roles of Calcium-Binding Proteins

In the intracellular environment, calcium functions as a second messenger to facilitate a wide variety of functions related to muscle contraction, neurotransmitter release, and enzyme activation. Additionally, calcium and calcium-binding proteins (CaBPs) are involved in almost every aspect of the...

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References

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of ChemistryGeorgia State UniversityAtlantaUSA
  2. 2.Natural Science CenterAtlantaUSA