Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Cadmium and Oxidative Stress

  • Ann Cuypers
  • Tony Remans
  • Vangronsveld Jaco
  • Karen Smeets
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_30

Synonyms

Definition

Oxidative stress is a process in which the cellular redox balance between pro- and antioxidants is disturbed in favor of the former.

Introduction

Cadmium (Cd) contamination is a widespread complication of industrial’s reliance on metals and the intensive use of agrochemicals containing Cd. Cadmium is not biodegradable, and therefore, the global environmental risk is constantly increasing due to its accumulation via the food chain. Furthermore, as Cd is classified as a type I carcinogenic element, it poses a serious threat to humans and animals but also other organisms, such as plants, fungi, and bacteria, present in all compartments of different ecosystems, are negatively affected by Cd.

Cadmium has a very high affinity for sulfhydryl (thiol) groups, and through binding with these functional groups of, for example, enzymes or structural proteins, it causes metabolic disruptions (Sharma and Dietz 2009; Cuypers et al. 2010...
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References

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Ann Cuypers
    • 1
  • Tony Remans
    • 1
  • Vangronsveld Jaco
    • 1
  • Karen Smeets
    • 1
  1. 1.Centre for Environmental SciencesHasselt UniversityDiepenbeekBelgium