Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Chromium Binding to DNA

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_3

Synonyms

Definition

Stable Cr-DNA binding is inner-sphere coordination of Cr(III) atoms with DNA groups. This type of binding can also be described as covalent coordinate bonding.

Cr-DNA Binding

General Characteristics of Chromium-DNA Binding

Human tissues and other biological systems usually encounter Cr in one of its two stable oxidative states, namely, +3 or +6. Although both inorganic Cr(III) and Cr(VI) compounds can cause Cr-DNA binding, the conditions required for this reaction to take place are not identical. At neutral pH, Cr(VI) is completely unreactive toward DNA and requires reductive activation to elicit genetic damage and other forms of biological injury. The reduction process is associated with a transient formation of Cr(V) and Cr(IV) intermediates, organic radicals as by-products, and finally yields thermodynamically...

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References

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Pathology and Laboratory MedicineBrown UniversityProvidenceUSA