Skip to main content

Cadmium Exposure, Cellular and Molecular Adaptations

  • Reference work entry
Encyclopedia of Metalloproteins
  • 126 Accesses

Synonyms

Adaptation: Acclimatization; Refitting

Resistance: Insusceptibility; Obstruction; Opposition; Resistivity

Definition

Adaptation: The fact for a living species to become better suited to its environment.

Resistance: The process of opposing the harmful threat of a toxic compound.

Speciation: Describes the associated forms in which elements, e.g., metals, occur in complex systems, such as a biological medium.

Redox: Acronym for oxidation-reduction. Here, refers to the set of reactions in which electrons can be exchanged within a cell.

Reactive oxygen species (ROS): Designates three oxygen-containing compounds, the superoxide radical anion, hydrogen peroxide, and hydroxyl radical, which all derive from dioxygen by successive reduction steps. By extension, ROS may refer to strongly oxidative (i.e., electron withdrawing) oxygen-containing molecules such as the hypochlorous anion or peroxynitrite.

Introduction

Cadmium compounds are overwhelmingly toxic in their interactions with...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 799.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 549.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Beyersmann D, Hechtenberg S (1997) Cadmium, gene regulation, and cellular signalling in mammalian cells. Toxicol Appl Pharmacol 144:247–261

    Article  CAS  PubMed  Google Scholar 

  • Clemens S (2006) Toxic metal accumulation, responses to exposure and mechanisms of tolerance in plants. Biochimie 88:1707–1719

    Article  CAS  PubMed  Google Scholar 

  • Cuypers A, Plusquin M, Remans T, Jozefczak M, Keunen E, Gielen H, Opdenakker K, Nair AR, Munters E, Artois TJ, Nawrot T, Vangronsveld J, Smeets K (2010) Cadmium stress: an oxidative challenge. Biometals 23:927–940

    Article  CAS  PubMed  Google Scholar 

  • Fauchon M, Lagniel G, Aude JC, Lombardia L, Soularue P, Petat C, Marguerie G, Sentenac A, Werner M, Labarre J (2002) Sulfur sparing in the yeast proteome in response to sulfur demand. Mol Cell 9:713–723

    Article  CAS  PubMed  Google Scholar 

  • Hartwig A (2010) Mechanisms in cadmium-induced carcinogenicity: recent insights. Biometals 23:951–960

    Article  CAS  PubMed  Google Scholar 

  • He L, Wang B, Hay EB, Nebert DW (2009) Discovery of ZIP transporters that participate in cadmium damage to testis and kidney. Toxicol Appl Pharmacol 238:250–257

    Article  CAS  PubMed  Google Scholar 

  • Klaassen CD, Liu J, Diwan BA (2009) Metallothionein protection of cadmium toxicity. Toxicol Appl Pharmacol 238:215–220

    Article  CAS  PubMed  Google Scholar 

  • Liu J, Qu W, Kadiiska MB (2009) Role of oxidative stress in cadmium toxicity and carcinogenesis. Toxicol Appl Pharmacol 238:209–214

    Article  CAS  PubMed  Google Scholar 

  • Maret W (2011) Redox biochemistry of mammalian metallothioneins. J Biol Inorg Chem 16(7):1079–1086

    Article  CAS  PubMed  Google Scholar 

  • Morel FM (2008) The co-evolution of phytoplankton and trace element cycles in the oceans. Geobiology 6:318–324

    Article  CAS  PubMed  Google Scholar 

  • Moulis JM (2010) Cellular mechanisms of cadmium toxicity related to the homeostasis of essential metals. Biometals 23:877–896

    Article  CAS  PubMed  Google Scholar 

  • Satarug S, Garrett SH, Sens MA, Sens DA (2010) Cadmium, environmental exposure, and health outcomes. Environ Health Perspect 118:182–190

    Article  CAS  PubMed  Google Scholar 

  • Thévenod F (2009) Cadmium and cellular signaling cascades: to be or not to be? Toxicol Appl Pharmacol 238:221–239

    Article  PubMed  CAS  Google Scholar 

  • Thévenod F (2010) Catch me if you can! Novel aspects of cadmium transport in mammalian cells. Biometals 23:857–875

    Article  PubMed  CAS  Google Scholar 

  • Villiers F, Ducruix C, Hugouvieux V, Jarno N, Ezan E, Garin J, Junot C, Bourguignon J (2011) Investigating the plant response to cadmium exposure by proteomic and metabolomic approaches. Proteomics 11:1650–1663

    Article  CAS  PubMed  Google Scholar 

  • Waalkes MP (2003) Cadmium carcinogenesis. Mutat Res 533:107–120

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jean-Marc Moulis .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media New York

About this entry

Cite this entry

Moulis, JM. (2013). Cadmium Exposure, Cellular and Molecular Adaptations. In: Kretsinger, R.H., Uversky, V.N., Permyakov, E.A. (eds) Encyclopedia of Metalloproteins. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1533-6_28

Download citation

Publish with us

Policies and ethics