Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Sodium-Hydrogen Exchangers, Structure and Function in Human Health and Disease

  • Larry Fliegel
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_249



Na+/H+ exchangers are a family of membrane proteins that exchange sodium for protons across lipid bilayers. They are widely distributed in all living cell types and are critical in several human diseases. The best known type of Na+/H+ exchanger in multicellular species is the mammalian Na+/H+ exchanger isoform 1 (NHE1). It is a plasma membrane protein that regulates intracellular pH by removing one intracellular hydrogen ion in exchange for one extracellular sodium ion. NHE1 regulates intracellular pH, but is also involved several diseases in the myocardium and in cancer, in addition to its role in cell growth, movement and differentiation. This review summarizes current knowledge of Na+/H+ exchangers, with emphasis on the most well characterized human Na+/H+ exchanger, the NHE1 isoform.

Introduction, Na+/H+ Exchangers

Na+/H+ exchangers are a class of membrane proteins that exchange Na+ for H+’s across lipid...

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Research by LF in this area is supported by the Canadian Institute of Health Research. LF is supported by an Alberta Ingenuity Medical Scientist award.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of BiochemistryUniversity of AlbertaEdmontonCanada