Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Sodium Channel Blockers and Activators

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_247



The term “sodium channel blockers” covers a wide range of naturally occurring and synthetic compounds that block the ion permeation through sodium-selective ion channels, large transmembrane proteins that control rapid membrane depolarization in electrically excitable cells. Due to their key roles in the cell physiology, sodium channels are targets for deadly toxins, which are synthesized by poisonous organisms as the attack or defense weapons, and for many therapeutic drugs. The latter are used to manage pain and treat various health disorders, including cardiac arrhythmias, heart attack, stroke, migraine, and epilepsy. Most of these compounds block the sodium channels. A broader term “sodium channel ligands” covers sodium channel blockers and compounds that modify gating of sodium channels. The gating modifiers include...

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This work was supported by grant GRPIN/238773-2009 from the Natural Sciences and Engineering Council of Canada.


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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Biochemistry and Biomedical SciencesMcMaster UniversityHamiltonCanada
  2. 2.Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of SciencesSt. PetersburgRussia