Definition
Voltage-gated sodium channels refer to members of the voltage-gated ion channel (VIC) superfamily, which are responsible for energy-independent transport of sodium ions. The opening of these channels is regulated by voltage, ligand, or receptor-binding. Voltage-gated sodium channels participate in transmission and propagation of action potentials in excitable tissues.
Basic Biological Roles of Voltage-Gated Ion Channels
Transmembrane transport is essential for all aspects of life, including uptake and excretion of nutrients, nucleic acids, ions, and drugs. Excitability of tissues accounts for the transmission of chemical and electrical signals in a wide range of organisms. Over 50 years ago, the participation of plasma membrane ion channels in cellular electrogenesis and excitability was described by the Hodgkin-Huxley model (1952). Such transmission and propagation of signals rely on the voltage-gated ion channels (VICs), which are known to transport...
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References
Brackenbury WJ, Djamgoz MBA, Isom LL (2008) An emerging role for voltage-gated Na+ channels in cellular migration: regulation of central nervous system development and potentiation of invasive cancers. Neuroscientist 14(6):571–583
Catterall WA (2010) Ion channel voltage sensors: structure function, and pathophysiology. Neuron 67(6):915–928
Fraser SP, Pardo LA (2008) Ion channels: functional expression and therapeutic potential in cancer. EMBO Rep 9(6):512–515
Hodgkin AL, Huxley AF (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol 117(4):500–544
Martinac B, Saimi Y, Kung C (2008) Ion channels in microbes. Physiol Rev 88(4):1449–1490
Prevarskaya N, Skryma R, Bidaux G, Flourakis M, Shuba Y (2007) Ion channels in death and differentiation of prostate cancer cells. Cell Death Differ 14(7):1295–1304
Prevarskaya N, Skryma R, Shuba Y (2010) Ion channels and the hallmarks of cancer. Trend Mol Med 16(3):107–121
Saier MH Jr (2003) Tracing pathways of transport protein evolution. Mol Microbiol 48(5):1145–1156
Tseng T-T, McMahon AM, Johnson VT, Mangubat EZ, Zahm RJ, Pacold ME, Jakobsson E (2007) Sodium channel auxiliary subunits. J Mol Microbiol Biotechnol
Yamashita N, Hamada H, Tsuruo T, Ogata E (1987) Enhancement of voltage-gated Na+ channel current associated with multidrug resistance in human leukemia cells. Cancer Res 47(14):3736–3741
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Tseng, TT. (2013). Sodium Channels, Voltage-Gated. In: Kretsinger, R.H., Uversky, V.N., Permyakov, E.A. (eds) Encyclopedia of Metalloproteins. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1533-6_246
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DOI: https://doi.org/10.1007/978-1-4614-1533-6_246
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