Sodium/Potassium-ATPase Structure and Function, Overview
ATP phosphohydrolase (Na+,K+, exchanging); EC 188.8.131.52; Na(+)/K(+)-exchanging ATPase; Na,K-activated ATPase; Na+/K+ pump; Sodium-potassium pump; Sodium pump; Sodium/potassium-exchanging ATPase; Sodium/potassium-transporting ATPase; Sodium-potassium adenosine triphosphatase; Sodium-potassium-dependent adenosine triphosphatase
The Na+,K+-ATPase is a transmembrane protein found in nearly all animal cells. It couples the energy released from the hydrolysis of the gamma phosphate of ATP to the transport of sodium and potassium ions across the cell membrane in a process called active transport. It is responsible, to a large extent, for the maintenance of transmembrane sodium and potassium concentration gradients and transmembrane electrical potential gradients. These gradients are in turn utilized by numerous biological processes, many of which are essential for higher-order life.
Most cells and particularly animal cells establish low...