Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Sodium/Potassium-ATPase Structure and Function, Overview

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_243



The Na+,K+-ATPase is a transmembrane protein found in nearly all animal cells. It couples the energy released from the hydrolysis of the gamma phosphate of ATP to the transport of sodium and potassium ions across the cell membrane in a process called active transport. It is responsible, to a large extent, for the maintenance of transmembrane sodium and potassium concentration gradients and transmembrane electrical potential gradients. These gradients are in turn utilized by numerous biological processes, many of which are essential for higher-order life.

Historical Perspective

Most cells and particularly animal cells establish low...

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  1. Garty H, Karlish SJD (2006) Role of FXYD proteins in ion transport. Annu Rev Physiol 68:431–459CrossRefPubMedGoogle Scholar
  2. Geering K (2008) Functional roles of Na, K-ATPase subunits. Curr Opin Nephrol Hypertens 17:526–532CrossRefPubMedGoogle Scholar
  3. Glynn IM (2002) A hundred years of sodium pumping. Annu Rev Physiol 64:1–18CrossRefPubMedGoogle Scholar
  4. Jorgensen PL, Hakansson KO, Karlish SJ (2003) Structure and mechanism of Na+, K+-ATPase functional sites and their interactions. Annu Rev Physiol 65:817–849CrossRefPubMedGoogle Scholar
  5. Kaplan JH (2002) Biochemistry of Na+, K+-ATPase. Annu Rev Biochem 71:511–535CrossRefPubMedGoogle Scholar
  6. Lingrel JB (2010) The physiological significance of the cardiotonic steroid/ouabain binding site of the Na+, K+-ATPase. Annu Rev Physiol 72:395–412CrossRefPubMedGoogle Scholar
  7. Martin DW (2005) Structure–function relationships in the Na+, K+-pump. Semin Nephrol 25:282–291CrossRefPubMedGoogle Scholar
  8. Morth JP, Pedersen BP, Buch-Pedersen MJ et al (2011) A structural overview of the plasma membrane Na+, K+-ATPase and H+-ATPase ion pumps. Nat Rev Mol Cell Biol 12:60–70CrossRefPubMedGoogle Scholar
  9. Ogawa H, Shinoda T, Cornelius F, Toyoshima C (2009) Crystal structure of the sodium-potassium pump (Na+, K+-ATPase) with bound potassium and ouabain. Proc Natl Acad Sci USA 106:13742–13747CrossRefPubMedGoogle Scholar
  10. Palmgren MG, Nissen P (2011) P-type ATPases. Annu Rev Biophys 40:243–266CrossRefPubMedGoogle Scholar
  11. Rice WJ, Young HS, Martin DW et al (2001) Structure of Na+, K+-ATPase at 11-Å resolution: comparison with Ca2+-ATPase in E1 and E2 states. Biophys J 80:2187–2197CrossRefPubMedGoogle Scholar
  12. Thever MD, Saier MH Jr (2009) Bioinformatic characterization of P-Type ATPases encoded within the fully sequenced genomes of 26 eukaryotes. J Membr Biol 229:115–130CrossRefPubMedGoogle Scholar
  13. Toyoshima C, Inesi G (2004) Structural basis of ion pumping by Ca2+-ATPase of the sarcoplasmic reticulum. Annu Rev Biochem 73:269–292CrossRefPubMedGoogle Scholar
  14. Toyoshima C, Mizutani T (2004) Crystal structure of the calcium pump with a bound ATP analog. Nature 430:529–535CrossRefPubMedGoogle Scholar
  15. Toyoshima C, Nomura H (2002) Structural changes in the calcium pump accompanying the dissociation of calcium. Nature 418:605–611CrossRefPubMedGoogle Scholar
  16. Toyoshima C, Nakasako M, Nomura H, Ogawa H (2000) Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 Å resolution. Nature 405:647–655CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Medicine and the Proteomics CenterStony Brook UniversityStony BrookUSA