Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Sodium-Binding Site Types in Proteins

  • Bogdan Lev
  • Benoît Roux
  • Sergei Yu. Noskov
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_242



Sodium: An alkali metal (Na) with atomic number 11. Sodium ion (Na+) is essential for numerous physiological functions including participation in the action potential generation, regulation of body fluid volume, and acid-base balance.

Sodium-binding protein: Any protein or enzyme that requires the binding of a sodium ion to its structural stability or functional activity.

Primary Active Transport: Substrate transport against its concentration gradient coupled to chemical energy, usually from hydrolysis of adenosine triphosphate.

Secondary Active Transport: Substrate transport against its concentration gradient coupled to electrochemical gradient created by ion concentration difference between extra- and intracellular milieus.

Na+ is among the most abundant elements on the planet. Several studies regarding the evolution of Na+-binding proteins suggest that its abundance in the water...

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Institute for Biocomplexity and Informatics, Department of Biological SciencesUniversity of CalgaryCalgaryCanada
  2. 2.Department of Pediatrics, Biochemistry and Molecular BiologyThe University of ChicagoChicagoUSA