Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Sodium-Binding Site Types in Proteins

  • Bogdan Lev
  • Benoît Roux
  • Sergei Yu. Noskov
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_242

Synonyms

Definitions

Sodium: An alkali metal (Na) with atomic number 11. Sodium ion (Na+) is essential for numerous physiological functions including participation in the action potential generation, regulation of body fluid volume, and acid-base balance.

Sodium-binding protein: Any protein or enzyme that requires the binding of a sodium ion to its structural stability or functional activity.

Primary Active Transport: Substrate transport against its concentration gradient coupled to chemical energy, usually from hydrolysis of adenosine triphosphate.

Secondary Active Transport: Substrate transport against its concentration gradient coupled to electrochemical gradient created by ion concentration difference between extra- and intracellular milieus.

Na+ is among the most abundant elements on the planet. Several studies regarding the evolution of Na+-binding proteins suggest that its abundance in the water...

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References

  1. Abramson J, Wright EM (2009) Structure and function of Na+-symporters with inverted repeats. Curr Opin Struct Biol 19:425–432CrossRefPubMedGoogle Scholar
  2. Boudker O et al (2007) Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter. Nature 445:387–393CrossRefPubMedGoogle Scholar
  3. Harding MM (2002) Metal-ligand geometry relevant to proteins and in proteins: sodium and potassium. Acta Cryst D 58:872–874CrossRefGoogle Scholar
  4. Mulkidjanian AY et al (2008) Evolutionary primacy of sodium bioenergetics. Biol Direct 3:13CrossRefPubMedGoogle Scholar
  5. Noskov SY, Roux B (2008) Control of ion selectivity in LeuT: two Na+ binding sites with two different mechanisms. J Mol Biol 377:804–818CrossRefPubMedGoogle Scholar
  6. Page MJ, Di Cera E (2006a) Is Na+ a coagulation factor? Thromb Haemost 95:920–921PubMedGoogle Scholar
  7. Page MJ, Di Cera E (2006b) Role of Na+ and K+ in enzyme function. Physiol Rev 86:1049–1092CrossRefPubMedGoogle Scholar
  8. Payandeh J, Scheuer T et al (2011) The crystal structure of a voltage-gated sodium channel. Nature 475:353–358CrossRefPubMedGoogle Scholar
  9. Yamashita A et al (2005) Crystal structure of a bacterial homologue of Na+/Cl–dependent neurotransmitter transporters. Nature 437:215–223CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Institute for Biocomplexity and Informatics, Department of Biological SciencesUniversity of CalgaryCalgaryCanada
  2. 2.Department of Pediatrics, Biochemistry and Molecular BiologyThe University of ChicagoChicagoUSA