Sodium-Binding Site Types in Proteins
Sodium: An alkali metal (Na) with atomic number 11. Sodium ion (Na+) is essential for numerous physiological functions including participation in the action potential generation, regulation of body fluid volume, and acid-base balance.
Sodium-binding protein: Any protein or enzyme that requires the binding of a sodium ion to its structural stability or functional activity.
Primary Active Transport: Substrate transport against its concentration gradient coupled to chemical energy, usually from hydrolysis of adenosine triphosphate.
Secondary Active Transport: Substrate transport against its concentration gradient coupled to electrochemical gradient created by ion concentration difference between extra- and intracellular milieus.
Na+ is among the most abundant elements on the planet. Several studies regarding the evolution of Na+-binding proteins suggest that its abundance in the water...