Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Sodium and Potassium Transport in Mammalian Mitochondria

  • Evgeny Pavlov
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_241

Synonyms

Definition

Mitochondrial sodium and potassium transport is a process of these ions movement between mitochondrial inner compartment (matrix) and cytoplasm of the cell. This process is highly regulated and provided by a number of molecular structures localized in the mitochondrial inner membrane. This transport can occur by the uniporter mechanism when either sodium or potassium is transported through corresponding selective channel or by the exchanger mechanism when sodium or potassium transport occurs in exchange of calcium or protons.

Introduction

Mitochondria are intracellular organelles found in nearly all types of eukaryotic cells. Morphologically, mitochondria can be described as membrane vesicles composed of two membranes. Outer mitochondrial membrane contains a number of large weakly selective channels (pores). Outer membrane regulates transport of small organic molecules (most...

This is a preview of subscription content, log in to check access.

References

  1. Bernardi P (1999) Mitochondrial transport of cations: channels, exchangers, and permeability transition. Physiol Rev 79(4):1127–1155PubMedGoogle Scholar
  2. Castaldo P, Cataldi M, Magi S, Lariccia V, Arcangeli S, Amoroso S (2009) Role of the mitochondrial sodium/calcium exchanger in neuronal physiology and in the pathogenesis of neurological diseases. Prog Neurobiol 87(1):58–79CrossRefPubMedGoogle Scholar
  3. Hajnoczky G, Csordas G (2010) Calcium signalling: fishing out molecules of mitochondrial calcium transport. Curr Biol 20(20):R888–R891CrossRefPubMedGoogle Scholar
  4. Murphy E, Eisner DA (2009) Regulation of intracellular and mitochondrial sodium in health and disease. Circ Res 104(3):292–303CrossRefPubMedGoogle Scholar
  5. Nishida H, Matsumoto A, Tomono N, Hanakai T, Harada S, Nakaya H (2010) Biochemistry and physiology of mitochondrial ion channels involved in cardioprotection. FEBS Lett 584(10):2161–2166CrossRefPubMedGoogle Scholar
  6. Szewczyk A, Jarmuszkiewicz W, Kunz WS (2009) Mitochondrial potassium channels. IUBMB Life 61(2):134–143CrossRefPubMedGoogle Scholar
  7. Szewczyk A, Kajma A, Malinska D, Wrzosek A, Bednarczyk P, Zablocka B, Dolowy K (2010) Pharmacology of mitochondrial potassium channels: dark side of the field. FEBS Lett 584(10):2063–2069CrossRefPubMedGoogle Scholar
  8. Zoratti M, Szabo I (1995) The mitochondrial permeability transition. Biochim Biophys Acta 1241(2):139–176CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Physiology & Biophysics, Faculty of MedicineDalhousie UniversityHalifaxCanada