Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Sodium and Potassium Transport in Mammalian Mitochondria

  • Evgeny Pavlov
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_241



Mitochondrial sodium and potassium transport is a process of these ions movement between mitochondrial inner compartment (matrix) and cytoplasm of the cell. This process is highly regulated and provided by a number of molecular structures localized in the mitochondrial inner membrane. This transport can occur by the uniporter mechanism when either sodium or potassium is transported through corresponding selective channel or by the exchanger mechanism when sodium or potassium transport occurs in exchange of calcium or protons.


Mitochondria are intracellular organelles found in nearly all types of eukaryotic cells. Morphologically, mitochondria can be described as membrane vesicles composed of two membranes. Outer mitochondrial membrane contains a number of large weakly selective channels (pores). Outer membrane regulates transport of small organic molecules (most...

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Physiology & Biophysics, Faculty of MedicineDalhousie UniversityHalifaxCanada