Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Cadmium and Stress Response

  • Masanori Kitamura
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_23



Exposure to cadmium results in cellular stress and evokes responses that involve injurious signaling and protective reactions. The most typical examples are oxidative stress and endoplasmic reticulum (ER) stress. Oxidative stress represents an imbalance between the production of reactive oxygen species (ROS) and the potential to detoxify ROS. The oxidative stress response comprises (1) generation of ROS and consequent modulation of cellular components including proteins, lipids, and DNA, leading to cellular activation or apoptosis and (2) induction of antioxidant systems that protect cells from ROS-mediated activation and cell injury. ER stress is defined as accumulation of unfolded proteins in the ER. It triggers an adaptive program, namely the unfolded protein response (UPR). The UPR alleviates ER stress by suppression of protein synthesis, facilitation of protein...

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and EngineeringUniversity of YamanashiChuoJapan