Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Cadmium and Stress Response

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_23

Synonyms

Definition

Exposure to cadmium results in cellular stress and evokes responses that involve injurious signaling and protective reactions. The most typical examples are oxidative stress and endoplasmic reticulum (ER) stress. Oxidative stress represents an imbalance between the production of reactive oxygen species (ROS) and the potential to detoxify ROS. The oxidative stress response comprises (1) generation of ROS and consequent modulation of cellular components including proteins, lipids, and DNA, leading to cellular activation or apoptosis and (2) induction of antioxidant systems that protect cells from ROS-mediated activation and cell injury. ER stress is defined as accumulation of unfolded proteins in the ER. It triggers an adaptive program, namely the unfolded protein response (UPR). The UPR alleviates ER stress by suppression of protein synthesis, facilitation of protein...

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References

  1. Cuypers A, Plusquin M, Remans T, Jozefczak M, Keunen E, Gielen H, Opdenakker K, Nair AR, Munters E, Artois TJ, Nawrot T, Vangronsveld J, Smeets K (2010) Cadmium stress: an oxidative challenge. Biometals 23:927–940CrossRefPubMedGoogle Scholar
  2. Kamata H, Hirata H (1999) Redox regulation of cellular signalling. Cell Signal 11:1–14CrossRefPubMedGoogle Scholar
  3. Kim R, Emi M, Tanabe K, Murakami S (2006) Role of the unfolded protein response in cell death. Apoptosis 11:5–13CrossRefPubMedGoogle Scholar
  4. Kitamura M (2008) Endoplasmic reticulum stress and unfolded protein response in renal pathophysiology: Janus faces. Am J Physiol – Renal 295:F323–F342CrossRefGoogle Scholar
  5. Kitamura M (2009) Biphasic, bidirectional regulation of NF-κB by endoplasmic reticulum stress. Antioxid Redox Signal 11:2353–2564CrossRefPubMedGoogle Scholar
  6. Kitamura M, Hiramatsu N (2010) The oxidative stress – endoplasmic reticulum stress axis in cadmium toxicity. Biometals 23:941–950CrossRefPubMedGoogle Scholar
  7. Liu J, Qu W, Kadiiska MB (2009) Role of oxidative stress in cadmium toxicity and carcinogenesis. Toxicol Appl Pharmacol 238:209–214CrossRefPubMedGoogle Scholar
  8. Malhotra JD, Kaufman RJ (2007) Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxid Redox Signal 9:2277–22793CrossRefPubMedGoogle Scholar
  9. Thevenod F (2003) Nephrotoxicity and the proximal tubule. Insights from cadmium. Nephron Physiol 93:87–93CrossRefGoogle Scholar
  10. Thévenod F (2009) Cadmium and cellular signaling cascades: to be or not to be? Toxicol Appl Pharmacol 238:221–239CrossRefPubMedGoogle Scholar
  11. Yokouchi M, Hiramatsu N, Hayakawa K, Kasai A, Takano Y, Yao J, Kitamura M (2007) Atypical, bidirectional regulation of cadmium-induced apoptosis via distinct signaling of unfolded protein response. Cell Death Differ 14:1467–1474CrossRefPubMedGoogle Scholar
  12. Yokouchi M, Hiramatsu N, Hayakawa K, Okamura M, Du S, Kasai A, Takano Y, Shitamura A, Shimada T, Yao J, Kitamura M (2008) Involvement of selective reactive oxygen species upstream of proapoptotic branches of unfolded protein response. J Biol Chem 283:4252–4260CrossRefPubMedGoogle Scholar
  13. Zhao Y, Tian T, Huang T, Nakajima S, Saito Y, Takahashi S, Yao J, Paton AW, Paton JC, Kitamura M (2011) Subtilase cytotoxin activates MAP kinases through PERK and IRE1 branches of the unfolded protein response. Toxicol Sci 120:79–89CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and EngineeringUniversity of YamanashiChuoJapan