Definition
Electrolyte metabolism refers to the processes that regulate the electrolyte composition of the body fluid compartments, which in turn regulates the distribution of water among the different compartments – and thus the cell volume. The movement of ions and other polar solutes through cellular membranes is catalyzed by membrane proteins. Transmembrane differences in the concentrations of K+, Na+, and Cl− are important for the generation of transmembrane potential differences. Transmembrane differences in the concentration of Na+ are important for the maintenance of cell volume.
In addition to being structural elements in proteins (Yamashita et al. 1990), the alkali metal cations, together with the halide anions, are important for the generation of transmembrane potential differences (Sten-Knudsen 2002) and the regulation of cell volume (Hoffmann et al. 2009). Transmembrane potential differences (or membrane potentials) are generated when the ion concentrations in the...
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Andersen OS, Ingólfsson HI, Lundbæk JA (2009) Ion channels. In: Bohr HG (ed) Handbook of molecular biophysics. Wiley-VCH, Weinheim, pp 557–592
Dai J, Sheetz MP, Wan X, Morris CE (1998) Membrane tension in swelling and shrinking molluscan neurons. J Neurosci 18:6681–6692
Finkelstein A (1987) Water movement through lipid bilayers, pores, and plasma membranes. Theory and reality. Wiley, New York
Hille B (2001) Ionic channels of excitable membranes, 3rd edn. Sinauer, Sunderland
Hoffmann EK, Lambert IH, Pedersen SF (2009) Physiology of cell volume regulation in vertebrates. Physiol Rev 89:193–277
Palmer LG, Andersen OS (2008) The two-membrane model of epithelial transport: Koefoed-Johnsen and Ussing (1958). J Gen Physiol 132:607–612
Roos A, Boron WF (1981) Intracellular pH. Physiol Rev 61:296–434
Sten-Knudsen O (2002) Biological membranes: theory of transport, potentials and electric impulses. Cambridge University Press, Cambridge
Yamashita MM, Wesson L, Eisenman G, Eisenberg D (1990) Where metal ions bind in proteins. Proc Natl Acad Sci USA 87:5648–5652
Zhou Z, Neher E (1993) Mobile and immobile calcium buffers in bovine adrenal chromaffin cells. J Physiol 469:245–273
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer Science+Business Media New York
About this entry
Cite this entry
Andersen, O.S. (2013). Cellular Electrolyte Metabolism. In: Kretsinger, R.H., Uversky, V.N., Permyakov, E.A. (eds) Encyclopedia of Metalloproteins. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1533-6_223
Download citation
DOI: https://doi.org/10.1007/978-1-4614-1533-6_223
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-1532-9
Online ISBN: 978-1-4614-1533-6
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences