Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Scandium, Interactions with Nucleotide and Nucleic Acids

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_200028

Definition

This entry refers to the interactions between scandium element/compounds and nucleic acids. Metal ion-nucleotide complexes have significant chemical and biological properties. Their structures have been studied extensively by various physical techniques such as NMR, IR, UV, and others.

Shyy et al. (1985) studied the interaction of scandium with adenosine 5′-triphosphate (ATP) by 17O NMR, 31P NMR, and 1H NMR, and confirmed the formation of 1:2 Sc(III)/ATP complex. The Sc(III)/ATP complexes are mixtures of rapidly exchanging diastereomers. The 17O NMR results showed that binding of Sc induced a small chemical shift effect and a large broadening effect for the line widths of [α-17O2]ATP, [β-17O2]ATP, and [γ-17O3]ATP. Comparison of the relative magnitudes of the line-broadening effect for all of the three phosphates of ATP suggested that the predominant macroscopic structure of Sc3+(ATP)2 is the α, β, γ-tridentate. Such a conclusion is further supported by 1H NMR. The strength...

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References

  1. Horovitz C (2000) Biochemistry of scandium and yttrium. Kluwer/Plenum, New YorkCrossRefGoogle Scholar
  2. Huang C, Li K, Tong S (1997) Fluorescence features of scandium (III)-8-hydroxyquinoline-nucleic acid systems and their analytical applications. Chin J Anal Chem 25:759–764Google Scholar
  3. Kulvelis Y, Lebedev V, Torok D et al (2007) Structure of the water salt solutions of DNA with sulfonated scandium diphthalocyanine. J Struct Chem 48:740–746CrossRefGoogle Scholar
  4. Shyy Y, Tsai T, Tsai M (1985) Metal-nucleotide interactions. 3. 17O, 31P, and 1H NMR studies on the interaction of scandium (III), lanthanum (III), and lutetium (III) with adenosine 5′-triphosphate. J Am Chem Soc 107:3478–3484CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety & CAS Key Laboratory of Nuclear Analytical TechniquesInstitute of High Energy Physics, Chinese Academy of SciencesBeijingChina