Scandium, Interactions with Globulin
This entry refers to the features of globulin and its interactions with scandium. Globulin is one of the three types of serum proteins, the others being albumin and fibrinogen. Globulins can be divided into three fractions based on their electrophoretic mobility. Most of the α- and β-globulins are synthesized by the liver, whereas γ-globulins are produced by lymphocytes and plasma cells in lymphoid tissue. α- and β-globulins are transport proteins, serve as substrates upon which other substances are formed, and perform other diverse functions. γ-globulins have a vital role in natural and acquired immunity to infection.
Scandium could bind to α-globulin. Rosoff and Spencer (1979) studied the binding of two Sc chelates to α-globulin and albumin in comparison to its chloride salt. The binding of ScEDDHA to α-globulin is about one-third that of the ScCl3 and the binding of the ScNTA is1/20 that of ScCl3. ScCl3and ScNTA are proved to bind more strongly to α-globulin than to...
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