Chromium(III) and Low Molecular Weight Peptides
Low-molecular-weight chromium-binding substance is a carboxylate-rich peptide isolated from the urine and tissues of higher animals that tightly binds Cr3+ ions. The peptide has been suggested to have a role in chromium detoxification and to potentially have a role in improving insulin sensitivity when animals are supplemented with high doses of chromium(III) compounds.
Chromium is absorbed by passive diffusion and then binds to the iron-transport protein in the blood. Transferrin delivers chromium to the tissues where it binds to a low-molecular-weight organic species that is cleared from the tissues. The chromium is ultimately eliminated from the body in the urine as a low-molecular-weight organic complex. This organic complex is called low-molecular-weight chromium-binding substance (LMWCr) and has also been coined chromodulin (Vincent and Stearns 2011).
Discovery of LMWCr
LMWCr was first...
- Vincent JB, Stearns DM (2011) The bioinorganic chemistry of chromium: essentiality, therapeutic agent, toxin, carcinogen? Wiley-Blackwell, ChichesterGoogle Scholar
- Wu GY, Wada O (1981) Studies on a specific chromium binding substance (a low-molecular-weight chromium binding substance) in urine. Jpn J Ind Health 23:505–512Google Scholar