Strontium, Calcium Analogue in Membrane Transport Systems
Strontium is a chemical element with symbol Sr and one of the alkaline earth metals. It was discovered in 1790 near the Scottish village Strontian and was eventually isolated in 1808. Strontium is found in group 2 of the periodic system, which also includes the biological important divalent metals magnesium (Mg) ( Magnesium in Biological Systems) and calcium (Ca) ( Calcium in Biological Systems). It is never found as a pure metal in nature since the metallic Sr is easily oxidized to form strontium oxide (SrO). Strontium is, however, often found trapped in minerals like celestite (SrSO4) and strontianite (SrCO3).
Strontium has attracted less attention than the more common divalent ions Mg2+ and Ca2+; important for human biology and pathology, however, the biological role of Sr has received increased interest since the introduction of strontium ranelate. This compound was the first antiosteoporotic agent reported to both stimulate bone formation...