Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Strontium Binding to Proteins

  • Vladimir N. Uversky
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_175

Synonyms

Definition

Due to the general similarity between the strontium and calcium ions (both metals are members of the alkaline earth series (Group IIB of the Periodic Table) that have many common properties, such that both have two positive charges in their ionic forms, similar ionic radii, and the ability to form complexes of various binding strengths), strontium can replace calcium to some extent in various biochemical processes in the body, for example, being able to interact with many calcium-binding proteins. Being heavier than calcium, strontium is frequently used as a tracer for calcium. It is also an important and useful analog of calcium in clinical research. Strontium has been safely used as a medicinal substance for more than a 100 years.

Some Physicochemical Properties of Strontium

The chemical element strontium is the 38th element in the chemical periodic table with the symbol of Sr, atomic number of 38, and atomic mass of the...

This is a preview of subscription content, log in to check access.

References

  1. Brandi ML (1993) New treatment strategies: ipriflavone, strontium, vitamin D metabolites and analogs. Am J Med 95:69S–74SCrossRefPubMedGoogle Scholar
  2. Brown EM, MacLeod RJ (2001) Extracellular calcium sensing and extracellular calcium signaling. Physiol Rev 81:239–297PubMedGoogle Scholar
  3. Cabrera WE, Schrooten I, De Broe ME, D’Haese PC (1999) Strontium and bone. J Bone Miner Res 14:661–668CrossRefPubMedGoogle Scholar
  4. Coulombe J, Faure H, Robin B, Ruat M (2004) In vitro effects of strontium ranelate on the extracellular calcium-sensing receptor. Biochem Biophys Res Commun 323:1184–1190CrossRefPubMedGoogle Scholar
  5. Decelle J, Suzuki N, Mahe F, de Vargas C, Not F (2012) Molecular phylogeny and morphological evolution of the Acantharia (Radiolaria). Protist 163:435–450CrossRefPubMedGoogle Scholar
  6. Giammarile F, Mognetti T, Blondet C, Desuzinges C, Chauvot P (1999) Bone pain palliation with 85Sr therapy. J Nucl Med 40:585–590PubMedGoogle Scholar
  7. Grynpas MD, Hamilton E, Cheung R, Tsouderos Y, Deloffre P, Hott M, Marie PJ (1996) Strontium increases vertebral bone volume in rats at a low dose that does not induce detectable mineralization defect. Bone 18:253–259CrossRefPubMedGoogle Scholar
  8. Harris H (1990) The human alkaline phosphatases: what we know and what we don’t know. Clin Chim Acta 186:133–150CrossRefPubMedGoogle Scholar
  9. Ingersoll RJ, Wasserman RH (1971) Vitamin D3-induced calcium-binding protein. Binding characteristics, conformational effects, and other properties. J Biol Chem 246:2808–2814PubMedGoogle Scholar
  10. Llinas P, Masella M, Stigbrand T, Menez A, Stura EA, Le Du MH (2006) Structural studies of human alkaline phosphatase in complex with strontium: implication for its secondary effect in bones. Protein Sci 15:1691–1700CrossRefPubMedGoogle Scholar
  11. Marie PJ (2005) Strontium ranelate: a novel mode of action optimizing bone formation and resorption. Osteoporos Int 16(Suppl 1):S7–S10CrossRefPubMedGoogle Scholar
  12. Permyakov EA, Berliner LJ (2000) α-Lactalbumin: structure and function. FEBS Lett 473:269–274CrossRefPubMedGoogle Scholar
  13. Pfleger H, Wolf HU (1975) Activation of membrane-bound high-affinity calcium ion-sensitive adenosine triphosphatase of human erythrocytes by bivalent metal ions. Biochem J 147:359–361PubMedGoogle Scholar
  14. Reginster JY, Deroisy R, Jupsin I (2003) Strontium ranelate: a new paradigm in the treatment of osteoporosis. Drugs Today (Barc) 39:89–101CrossRefGoogle Scholar
  15. Rinaldo D, Vita C, Field MJ (2004) Engineering strontium binding affinity in an EF-hand motif: a quantum chemical and molecular dynamics study. J Biomol Struct Dyn 22:281–297CrossRefPubMedGoogle Scholar
  16. Sandier A, Amiel C, Sebille B, Rouchaud JC, Fedoroff M (1999) A study of strontium binding to albumins, by a chromatographic method involving atomic emission spectrometric detection. Int J Biol Macromol 24:43–48CrossRefPubMedGoogle Scholar
  17. Schaer JJ, Milos M, Cox JA (1985) Thermodynamics of the binding of calcium and strontium to bovine alpha-lactalbumin. FEBS Lett 190:77–80CrossRefPubMedGoogle Scholar
  18. Schrooten I, Cabrera W, Goodman WG, Dauwe S, Lamberts LV, Marynissen R, Dorrine W, De Broe ME, D’Haese PC (1998) Strontium causes osteomalacia in chronic renal failure rats. Kidney Int 54:448–456CrossRefPubMedGoogle Scholar
  19. Shirran SL, Barran PE (2009) The use of ESI-MS to probe the binding of divalent cations to calmodulin. J Am Soc Mass Spectrom 20:1159–1171CrossRefPubMedGoogle Scholar
  20. Wasserman RH (1998) Strontium as a tracer for calcium in biological and clinical research. Clin Chem 44:437–439PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Molecular MedicineUniversity of South Florida, College of MedicineTampaUSA