Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Chromium(III) and Transferrin

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_17

Synonyms

Definition

Transferrins comprise a class of proteins with molecular weights of approximately 80,000 that reversibly bind two equivalents of metal ions. The proteins selectively bind ferric ions in a biological environment because the metal-binding sites are adapted to bind ions with large charge-to-size ratios. Transferrin is a blood serum protein, a β-globulin, although other forms of the protein are found in milk (lactoferrin) and avian egg white (conalbumin or ovotransferrin). Transferrin is the major iron transport protein in the bloodstream, while lactoferrin and conalbumin are believed to have antibacterial roles by depriving bacteria of iron. Because of its similarity in size and charge to ferric ion, Cr3+ is transported and stored in the bloodstream by transferrin.

Transferrins are a class of proteins of approximately 80 kDa (kilodaltons) that reversibly bind two equivalents of metal ions (Brock 1985). The...

This is a preview of subscription content, log in to check access.

References

  1. Ainscough EW, Brodie AM, Plowman JE (1979) The chromium, manganese, cobalt and copper complexes of human lactoferrin. Inorg Chim Acta 33:149–153CrossRefGoogle Scholar
  2. Ainscough EW, Brodie AM, Plowman JE, Bloor SJ, Sanders Loehr J, Loehr TM (1980) Studies on human lactoferrin by electron paramagnetic resonance, fluorescence, and resonance Raman spectroscopy. Biochemistry 19:4072–4079CrossRefPubMedGoogle Scholar
  3. Aisen P, Aasa R, Redfield AG (1969) The chromium, manganese, and cobalt complexes of transferrin. J Biol Chem 244:4628–4633PubMedGoogle Scholar
  4. Baker EN (1994) Structure and reactivity transferrins. Adv Inorg Chem 41:389–463CrossRefGoogle Scholar
  5. Brock JH (1985) Transferrins. In: Harrison PM (ed) Metalloproteins, Part 2. Verlag Chemie, WeinheimGoogle Scholar
  6. Clodfelder BJ, Vincent JB (2005) The time-dependent transport of chromium in adult rats from the bloodstream to the urine. J Biol Inorg Chem 10:383–393CrossRefPubMedGoogle Scholar
  7. Hopkins LL Jr, Schwarz K (1964) Chromium(III) binding to serum proteins, specifically siderophilin. Biochim Biophys Acta 90:484–491CrossRefPubMedGoogle Scholar
  8. Sun Y, Ramirez J, Woski SA, Vincent JB (2000) The binding of chromium to low-molecular-weight chromium-binding substance (LMWCr) and the transport of chromium from transferring and chromium picolinate to LMWCr. J Biol Inorg Chem 5:129–136CrossRefPubMedGoogle Scholar
  9. Vincent JB, Stearns DM (2011) The bioinorganic chemistry of chromium: essentiality, therapeutic agent, toxin, carcinogen? Wiley-Blackwell, ChichesterGoogle Scholar
  10. Yamamoto A, Wada O, Ono T (1984) Distribution and chromium-binding capacity of a low-molecular-weight, chromium-binding substance in mice. J Inorg Biochem 22:91–102CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of ChemistryThe University of AlabamaTuscaloosaUSA