Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Chromium and Insulin Signaling

  • Zbigniew KrejpcioEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_16



Insulin signaling refers to the cascade of processes triggered by insulin binding with its receptor, and as a result, cellular glucose uptake and utilization can take place. It has been extensively documented that trivalent chromium (Cr3+) can improve insulin sensitivity by enhancing insulin signal transduction; however, the mechanisms of its action have not been fully understood. The contemporary theories explaining the possible mechanisms of Cr3+ action in insulin signaling are based on certain phenomena that include its role in the LMWCr, involvement in phosphorylation reactions, assisting insulin binding to its receptor, increasing number of insulin receptors, activation of Akt proteins, and interaction with cytokines and oxidation processes, as well as increasing cell membrane fluidity.

Insulin Signaling

Insulin (INS) is a hormone with pleiotropic functions that influences gene...

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Division of Food Toxicology and Hygiene, Department of Human Nutrition and HygieneThe Poznan University of Life SciencesPoznanPoland
  2. 2.The College of Health, Beauty and Education in PoznanPoznanPoland