Definition
This entry refers to the ways of exposure of various biological systems to aluminum and to the mechanisms underlying the interactions of the element with these systems. Concerns on aluminum toxicity on ecosystems gain interest in view of the continuously increasing use of aluminum compounds in industry and acid rain.
Introduction
Despite the ubiquity of aluminum (Al) in the environment and its presence in living organisms, be it in small amounts (ppb-ppm range), no biological function has so far been attributed to the element. For this reason aluminum is considered a nonessential metal. It has long been thought that aluminum was inert for living organisms and as such was not regarded as a toxic element until the 1960s. At that time, only a few reports dealt with the toxic effects of aluminum in humans and animals, which, however, did not receive much attention. In the 1970s, aluminum exposure was linked...
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Buchta AM, Kiesswetter BE, Schäper BM, Zschiesche CW, Schaller DKH, Kuhlmann AA, Letzel AS (2005) Neurotoxicity of exposures to aluminium welding fumes in the truck trailer construction industry. Environ Toxicol Pharmacol 19(3):677–685
D’Haese PC, De Broe ME (1999) Trace metals in chronic renal failure patients treated by dialysis. Trace Elem Electrolytes 16(4):163–174 (Review)
D’Haese PC, De Broe ME (2007) Aluminum, lanthanum and strontium. In: Daugirdas JT, Blake PG, Ing TS (eds) Handbook of dialysis, 4th edn. Wolters Kluwer, Philadelphia
De Broe ME, Coburn JW (eds) (1990) Aluminum and renal failure. Kluwer, Dordrecht
Donoghue AM, Frisch N, Ison M, Walpole G, Capil R, Curl C, Di Corleto R, Hanna B, Robson R, Viljoen D (2011) Occupational asthma in the aluminum smelters of Australia and New Zealand: 1991–2006. Am J Ind Med 54(3):224–231
Kawahara M, Kato-Negishi M (2011) Pathogenesis of Alzheimer’s disease: the integration of the aluminum and amyloid cascade hypotheses. Int J Alzheimers Dis, Article ID 276393, 17 pages, doi:10.4061/2011/276393
Martyn CN, Osmond C, Edwardson JA, Barker DJP, Harris EC, Lacey RF (1989) Geographical relation between Alzheimer’s disease and aluminium in drinking water. Lancet 1(8629):59–62
Mitkus RJ, King DB, Hess MA, Forshee RA, Walderhaug MO (2011) Updated aluminum pharmacokinetics following infant exposures through diet and vaccination. Vaccine 29(51):9538–9543
Nayak P (2002) Aluminum: impacts and disease. Environ Res 89(2):101–115 (Review)
Van Landeghem GF (1997) Aluminum speciation in biological fluids. Implications for patients with end stage renal failure. Ph.D. thesis, University of Leiden, Leiden (ISBN 90-9010801-7)
White KN, Ejim AI, Walton RC, Brown AP, Jugdaohsingh R, Powell JJ, McCrohan CR (2008) Avoidance of aluminum toxicity in freshwater snails involves intracellular silicon-aluminum biointeraction. Environ Sci Technol 42(6):2189–2194
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer Science+Business Media New York
About this entry
Cite this entry
D’Haese, P.C. (2013). Aluminum, Biological Effects. In: Kretsinger, R.H., Uversky, V.N., Permyakov, E.A. (eds) Encyclopedia of Metalloproteins. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1533-6_110
Download citation
DOI: https://doi.org/10.1007/978-1-4614-1533-6_110
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-1532-9
Online ISBN: 978-1-4614-1533-6
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences